CAS 72559-06-9
:Rifabutin
Description:
Rifabutin is an antibiotic belonging to the rifamycin class, primarily used in the treatment of tuberculosis and certain other bacterial infections, particularly in patients with HIV. Its chemical structure features a complex bicyclic system that includes a naphthalene ring, contributing to its antimicrobial activity. Rifabutin works by inhibiting bacterial RNA synthesis through binding to the DNA-dependent RNA polymerase, effectively disrupting the transcription process. This mechanism makes it effective against a range of mycobacterial species. The substance is known for its relatively favorable pharmacokinetic profile, allowing for once-daily dosing, which enhances patient compliance. Additionally, it has a lower propensity for drug interactions compared to other rifamycins, making it a preferred choice in co-infected patients. Common side effects may include gastrointestinal disturbances, rash, and changes in urine color. Due to its specific use and potential for resistance, rifabutin is typically prescribed in conjunction with other antitubercular agents. Its CAS number, 72559-06-9, uniquely identifies this compound in chemical databases.
Formula:C46H62N4O11
InChI:InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14+/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
InChI key:InChIKey=ATEBXHFBFRCZMA-NYGPAKPVSA-N
SMILES:O=C1C=2C=3C=4C(=C5C(=O)C3C(O)=C(C)C2O[C@]1(C)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(\C)/C(=O)N5)NC6(N4)CCN(CC(C)C)CC6
Synonyms:- Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2′,3′:7,8]naphth[1,2-d]imidazole-2,4′-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1′-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-
- (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-(Acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1′-(2-methylpropyl)spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2′,3′:7,8]naphth[1,2-d]imidazole-2,4′-piperidine]-5,10,26(3H,9H)-trione
- Antibiotic LM 427
- Rifamycin XIV, 1′,4-didehydro-1-deoxy-1,4-dihydro-5′-(2-methylpropyl)-1-oxo-
- Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2′,3′:7,8]naphth[1,2-d]imidazole-2,4′-piperidine], rifamycin XIV deriv.
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Rifabutin
CAS:Formula:C46H62N4O11Purity:>98.0%(HPLC)Color and Shape:Red to Dark red to Dark purple powder to crystalMolecular weight:847.02RIFABUTIN CRS
CAS:RIFABUTIN CRSFormula:C46H62N4O11Color and Shape:Amorphous. Reddish-Violet. Powder.Molecular weight:847.0047Rifabutin
CAS:Antibiotics nesoiFormula:C46H62N4O11Color and Shape:Dark Violet PowderMolecular weight:847Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formula:C46H62N4O11Purity:98.87% - 99.7%Color and Shape:SolidMolecular weight:847.00Rifabutin
CAS:Formula:C46H62N4O11Purity:95.0 - 102.0 % (anhydrous basis)Color and Shape:Red to purple powderMolecular weight:847.00Rifabutin
CAS:Inhibitor of bacterial DNA-dependent RNA polymeraseFormula:C46H62N4O11Purity:Min. 97.5 Area-%Color and Shape:PowderMolecular weight:847 g/molRifabutin
CAS:(9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-(Acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1′-(2-methylpropyl)spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2′,3′:7,8]naphth[1,2-d]imidazole-2,4′-piperidine]-5,10,26(3H,9H)-trioneFormula:C46H62N4O11Purity:98%Molecular weight:847.0
