CAS 72581-71-6

Isosilybin

Description:

Isosilybin is a flavonoid compound derived from the milk thistle plant, Silybum marianum, known for its potential health benefits, particularly in liver protection and antioxidant activity. It is a stereoisomer of silybin, which is one of the primary active constituents of milk thistle. Isosilybin exhibits a complex structure characterized by multiple hydroxyl groups, contributing to its biological activity. The compound is recognized for its ability to scavenge free radicals, thereby reducing oxidative stress in cells. Additionally, isosilybin has been studied for its potential role in modulating various signaling pathways, which may have implications in cancer prevention and treatment. Its solubility properties are influenced by its chemical structure, affecting its bioavailability and efficacy. Research continues to explore the pharmacological effects of isosilybin, including its hepatoprotective properties and potential therapeutic applications in various diseases. Overall, isosilybin represents a significant area of interest in natural product chemistry and pharmacology.

Formula: C₂₅H₂₂O₁₀

InChI: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1

InChI key: InChIKey=FDQAOULAVFHKBX-DBMPWETRSA-N

SMILES: C(O)C1C(OC=2C(O1)=CC(=CC2)[C@H]3OC=4C(C(=O)[C@@H]3O)=C(O)C=C(O)C4)C5=CC(OC)=C(O)C=C5

Synonyms:

• (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
• (2R,3R)-3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
• 1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.
• 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
• 3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
• 4H-1-Benzopyran-4-one, 2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
• Isosilibinin
• Isosilybinin
• Isosilybin

isosilybin

CAS: 72581-71-6

Formula: C₂₅H₂₂O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.4362

Ref: IN-DA0063TT

Isosilybin (Mixture of Diastereomers)

CAS: 72581-71-6

Formula: C₂₅H₂₂O₁₀

Color and Shape: White To Off-White Solid

Molecular weight: 482.44

Ref: 4Z-S-399

Isosilybin

CAS: 72581-71-6

Isosilybin

Purity: ≥98%

Molecular weight: 482.44g/mol

Ref: 54-BUP02881

Isosilybin

CAS: 72581-71-6

Formula: C₂₅H₂₂O₁₀

Molecular weight: 482.44

Ref: 7W-GY1607

Isosilybin

CAS: 72581-71-6

Formula: C₂₅H₂₂O₁₀

Purity: 95%~99%

Molecular weight: 482.441

Ref: BP-BP0800

Isosilybin

CAS: 72581-71-6

Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer

Formula: C₂₅H₂₂O₁₀

Purity: 98% - 99.92%

Color and Shape: Solid

Molecular weight: 482.44

Ref: TM-T3797

Isosilybin (a + b mixture)

CAS: 72581-71-6

Oxygen-heterocyclic compound

Formula: C₂₅H₂₂O₁₀

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 482.44

Ref: 5G-89231

Isosilybin (isomeric mixture of isosilybin A&B)

CAS: 72581-71-6

Anti-oxidant; hepatoprotective; anti-cancer; hypocholesterolemic

Formula: C₂₅H₂₂O₁₀

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 482.44 g/mol

Ref: 3D-FI24728

Isosilybin

CAS: 72581-71-6

Purity: 99.82%

Molecular weight: 482.441

Ref: 10-F979081

Isosilybin

Controlled Product

CAS: 72581-71-6

Applications Useful in the treatment of liver disease.
References Parthasarathy, M.R., et al.: Phytochemistry, 18, 506 (1979),

Formula: C₂₅H₂₂O₁₀

Color and Shape: Neat

Molecular weight: 482.44

Ref: TR-I901000