CAS 72590-77-3

Hydrocortisone buteprate

Description:

Hydrocortisone buteprate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is primarily used in dermatological formulations to treat various skin conditions, including eczema, dermatitis, and psoriasis. The compound is characterized by its ability to reduce inflammation and alleviate symptoms such as redness, itching, and swelling. Hydrocortisone buteprate acts by inhibiting the release of inflammatory mediators and modulating immune responses. Its formulation typically includes a butyrate ester, which enhances skin penetration and prolongs its therapeutic effects. The substance is generally well-tolerated, but potential side effects may include skin irritation or atrophy with prolonged use. As with other corticosteroids, it is important to use hydrocortisone buteprate under medical supervision to minimize risks associated with systemic absorption and to ensure appropriate dosing. Overall, hydrocortisone buteprate is a valuable agent in the management of inflammatory skin disorders, providing effective relief while maintaining a favorable safety profile when used correctly.

Formula: C₂₈H₄₀O₇

InChI: InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1

InChI key: InChIKey=FOGXJPFPZOHSQS-AYVLZSQQSA-N

SMILES: C(COC(CC)=O)(=O)[C@]1(OC(CCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])[H]

Synonyms:

• (11Beta)-11-Hydroxy-3,20-Dioxo-21-(Propanoyloxy)Pregn-4-En-17-Yl Butanoate
• (11β)-11-Hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)pregn-4-ene-3,20-dione
• (9Xi,11Beta)-11-Hydroxy-3,20-Dioxo-21-(Propanoyloxy)Pregn-4-En-17-Yl Butanoate
• 17α-Butyryloxy-11β-hydroxy-21-propionyloxy-4-pregnene-3,20-dione
• Hydrocortisone 17-butyrate 21-propionate
• Hydrocortisone Probutate
• Hydrocortisone buteprate
• Pandel
• Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)-, (11β)-
• Ts 408

Hydrocortisone buteprate, 10mM (in DMSO)

CAS: 72590-77-3

Hydrocortisone buteprate, 10mM (in DMSO)

Purity: ≥95%

Molecular weight: 488.61g/mol

Ref: 54-BUP22150

Hydrocortisone buteprate

CAS: 72590-77-3

Hydrocortisone buteprate is a medium-potent, non-halogenated double-ester of hydrocortisone with a highly favorable benefit-to-risk ratio for inflammatory skin disorders.

Formula: C₂₈H₄₀O₇

Purity: 99.19%

Color and Shape: Solid

Molecular weight: 488.61

Ref: TM-T13728

Hydrocortisone 17-Butyrate 21-Propionate

CAS: 72590-77-3

Color and Shape: Neat

Ref: 86-MM0189.00

Hydrocortisone 17-Butyrate 21-Propionate

Controlled Product

CAS: 72590-77-3

Applications A synthetic adrenocorticosteroid that acts as an anti-inflammatory and anti-pruritic agents. It is used as a topical for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis.
References Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981);

Formula: C₂₈H₄₀O₇

Color and Shape: White To Off-White

Molecular weight: 488.61

Ref: TR-H714665

Hydrocortisone 17-butyrate 21-propionate

Controlled Product

CAS: 72590-77-3

Hydrocortisone 17-butyrate 21-propionate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. This drug is a prodrug that is hydrolyzed in the liver to hydrocortisone, its active form, by esterases. Hydrocortisone 17-butyrate 21-propionate has been used to treat inflammatory bowel disease and various skin disorders. It also has been shown to inhibit the production of malonic acid, which may be due to inhibition of fatty acid synthase and/or enhanced absorption of hydrocortisone from the gastrointestinal tract. The drug also interacts with other drugs such as dimethyl fumarate, which inhibits the metabolism of hydrocortisone by cytochrome P450 enzymes. This can lead to increased blood concentrations of hydrocortisone and serious side effects such as metabolic disorders or high blood pressure.

Formula: C₂₈H₄₀O₇

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 488.61 g/mol

Ref: 3D-FH23884