CAS 72599-27-0

Miglustat

Description:

Miglustat is a chemical compound primarily used as a therapeutic agent for certain genetic disorders, particularly Gaucher disease and Niemann-Pick disease type C. It is classified as a glucosylceramidase inhibitor, which means it interferes with the metabolism of glycosphingolipids, thereby reducing their accumulation in cells. The molecular formula of miglustat is C₈H₁₅NO₃, and it has a molecular weight of approximately 169.22 g/mol. The compound is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it beneficial for neurological manifestations of these diseases. Miglustat is characterized by its white to off-white crystalline powder form, and it is soluble in water and organic solvents. Its mechanism of action involves the inhibition of the enzyme glucosylceramidase, which is crucial for the breakdown of glucocerebrosides. As with any medication, miglustat may have side effects, and its use should be monitored by healthcare professionals.

Formula: C₁₀H₂₁NO₄

InChI: InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1

InChI key: InChIKey=UQRORFVVSGFNRO-UTINFBMNSA-N

SMILES: C(CCC)N1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1

Synonyms:

• N-Butyl-1-deoxynojirimycin
• 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, [2R-(2α,3β,4α,5β)]-
• 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3R,4R,5S)-
• N-Butyldeoxynojirimycin
• (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol

N-Butyldeoxynojirimycin, 98%

CAS: 72599-27-0

An alpha-glucosidase Inhibitor

Purity: 98%

Ref: 02-J66613

N-Butyldeoxynojirimycin·HCl

CAS: 72599-27-0

Formula: C₁₀H₂₁NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 219.2780

Ref: IN-DA005QP0

Miglustat

CAS: 72599-27-0

Miglustat (NB-DNJ), derived from deoxynojirimycin, inhibits glucosylceramide synthase to manage Gaucher disease Type I.

Formula: C₁₀H₂₁NO₄

Purity: 99.92%

Color and Shape: Solid

Molecular weight: 219.28

Ref: TM-T12039

N-(n-Butyl)-1-deoxynojirimycin

CAS: 72599-27-0

N-(n-Butyl)-1-deoxynojirimycin

Purity: >99%

Color and Shape: Solid

Molecular weight: 219.28g/mol

Ref: 54-BICL4040

Miglustat

CAS: 72599-27-0

Miglustat

Purity: ≥98%

Molecular weight: 219.28g/mol

Ref: 54-BUP04233

Miglustat

CAS: 72599-27-0

Formula: C₁₀H₂₁NO₄

Purity: 99%

Molecular weight: 219.281

Ref: BP-BP5229

N-Butyldeoxynojirimycin

CAS: 72599-27-0

Formula: C₁₀H₂₁NO₄

Purity: ≥ 98.0%

Color and Shape: White solid

Molecular weight: 219.28

Ref: 7W-GC5657

N-Butyldeoxynojirimycin

CAS: 72599-27-0

Competitive inhibitor of ceramide-glycosyltransferase used for substrate reduction therapy in lysosomal storage disorders. It inhibits glucosylceramide synthase, which catalyses the initial step in glycosphingolipid biosynthetic pathway. This compound delays the onset of symptoms in type 1 Gaucher disease, Sandhoff disease and Tay-Sachs disease. It also reduces brain abnormalities in mucolipidosis type IV.

Formula: C₁₀H₂₁NO₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 219.28 g/mol

Ref: 3D-MB06729

N-BUTYL-1-DEOXYNOJIRIMYCIN

CAS: 72599-27-0

Formula: C₁₀H₂₁NO₄

Purity: 97%

Molecular weight: 219.281

Ref: 10-F534968