CAS 7261-97-4
:Dantrolene
Description:
Dantrolene is a muscle relaxant primarily used to treat conditions such as malignant hyperthermia and spasticity associated with neurological disorders. It functions by inhibiting calcium release from the sarcoplasmic reticulum in skeletal muscle, thereby reducing muscle contraction. Dantrolene is a hydantoin derivative and is characterized by its chemical formula, which includes a dantrolene structure that features a hydantoin ring. It is typically administered in its sodium salt form, which enhances its solubility in water. The substance is known for its relatively low bioavailability when taken orally, often necessitating intravenous administration in acute settings. Common side effects may include muscle weakness, drowsiness, and gastrointestinal disturbances. Due to its mechanism of action, dantrolene is unique among muscle relaxants, as it directly targets muscle cells rather than the central nervous system. Its use requires careful monitoring, especially in patients with liver dysfunction, as it can lead to hepatotoxicity. Overall, dantrolene is a critical medication in specific medical emergencies and chronic conditions involving muscle spasticity.
Formula:C14H10N4O5
InChI:InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)
InChI key:InChIKey=OZOMQRBLCMDCEG-UHFFFAOYSA-N
SMILES:C(=NN1CC(=O)NC1=O)C=2OC(=CC2)C3=CC=C(N(=O)=O)C=C3
Synonyms:- 1-({(1E)-[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione
- 1-({[5-(4-Nitrophenyl)-2-furyl]methylene}amino)imidazolidine-2,4-dione
- 1-({[5-(4-Nitrophenyl)Furan-2-Yl]Methylidene}Amino)Imidazolidine-2,4-Dione
- 1-[[5-(p-Nitrophenyl)furfurylidene]amino]hydantoin
- 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione
- 2,4-Imidazolidinedione, 1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-
- 230-684-8
- Dantrolen
- Dantroleno
- F 368
- Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-
- See more synonyms
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Found 10 products.
Dantrolene-d4
CAS:Formula:C14H6D4N4O5Color and Shape:Yellow To Light Brown SolidMolecular weight:318.28Dantrolene
CAS:Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.Formula:C14H10N4O5Purity:99.97%Color and Shape:Crystals From Aq DimethylformamideMolecular weight:314.25Dantrolene
CAS:Controlled Product<p>Applications Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.<br>References Zhao, F. et al.: J. Biol. Chem., 276, 13810 (2001); Krause, T. et al.: 59, 364 (2004);<br></p>Formula:C14H10N4O5Color and Shape:Dark YellowMolecular weight:314.251-{{[5-(4-Nitrophenyl)-2-furanyl]methylene}amino}-2,4-imidazolidinedione
CAS:<p>Dantrolene is an experimental model for malignant hyperthermia, a rare genetic condition that can cause muscle rigidity and death. Dantrolene has been shown to inhibit the activity of the dinucleotide phosphate (NADH) dehydrogenase enzyme in muscle cells. In addition, it inhibits calcium release from the sarcoplasmic reticulum and activates ryanodine receptors. Dantrolene also inhibits muscle contractions and prevents neuronal death by inhibiting the release of glutamate.</p>Formula:C14H10N4O5Purity:Min. 95%Color and Shape:SolidMolecular weight:314.25 g/molDantrolene Sodium Salt Hydrate
CAS:Formula:C14H9N4NaO5·xH2OPurity:>98.0%(T)(HPLC)Color and Shape:Orange to Brown powder to crystalMolecular weight:336.24 (as Anhydrous)Dantrolene
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C14H10N4O5Color and Shape:Yellow Light Yellow Crystalline PowderMolecular weight:314.06512
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