CAS 726169-73-9

Mocetinostat

Description:

Mocetinostat, with the CAS number 726169-73-9, is a small molecule inhibitor primarily known for its role as a histone deacetylase (HDAC) inhibitor. It is characterized by its ability to modulate gene expression by altering the acetylation status of histones, thereby influencing chromatin structure and function. This compound has been investigated for its potential therapeutic applications in various cancers, particularly in hematological malignancies and solid tumors. Mocetinostat exhibits selectivity towards certain HDAC isoforms, which contributes to its efficacy and safety profile. In addition to its anticancer properties, research has indicated that it may have effects on immune modulation and differentiation of cells. The compound is typically administered orally and has been evaluated in clinical trials, showcasing its potential as part of combination therapies. As with many HDAC inhibitors, the pharmacodynamics and pharmacokinetics of mocetinostat are critical for understanding its therapeutic window and optimizing its use in clinical settings.

Formula: C₂₃H₂₀N₆O

InChI: InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29)

InChI key: InChIKey=HRNLUBSXIHFDHP-UHFFFAOYSA-N

SMILES: N(CC1=CC=C(C(NC2=C(N)C=CC=C2)=O)C=C1)C=3N=C(C=CN3)C=4C=CC=NC4

Synonyms:

• Mg 0103
• Mgcd 0103
• Mocetinostat
• N-(2-Aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide
• N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide
• N-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide
• benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

CAS: 726169-73-9

Formula: C₂₃H₂₀N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 396.4445

Ref: IN-DA0039AL

Mocetinostat

CAS: 726169-73-9

Mocetinostat

Purity: ≥98%

Molecular weight: 396.44g/mol

Ref: 54-BUP10540

Mocetinostat

CAS: 726169-73-9

Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.

Formula: C₂₃H₂₀N₆O

Purity: 99% - 99.21%

Color and Shape: Solid

Molecular weight: 396.44

Ref: TM-T2512

Mocetinostat

Controlled Product

CAS: 726169-73-9

Applications Mocetinostat is a multi-targeted histone deacetylase inhibitor used in cancer therapy. Mocetinostat is undergoing clinical trials for the treatment of various cancers including follicular lymphoma, Hodgkin’s lymphoma and acute myelogenous leukemia.
References Ai, T., et al.: Curr. Med. Chem., 19, 475 (2012); Cacasin, M.A., et al.: Circulation Rsch., 110, 739 (2012); Younes, A., et al.: Lancet Oncol., 12, 1222 (2011);

Formula: C₂₃H₂₀N₆O

Color and Shape: Neat

Molecular weight: 396.44

Ref: TR-M481090

Mocetinostat

CAS: 726169-73-9

Inhibitor of class I histone deacetylases

Formula: C₂₃H₂₀ON₆

Purity: Min. 95%

Molecular weight: 396.44 g/mol

Ref: 3D-FM34131