CAS 72698-36-3

N-succinyl-gly-pro-leu-gly-pro 7-*amido-4-methylc

Description:

N-succinyl-gly-pro-leu-gly-pro 7-amido-4-methylcoumarin, identified by the CAS number 72698-36-3, is a synthetic peptide derivative that exhibits specific biochemical properties. This compound is characterized by its structure, which includes a succinyl group and a sequence of amino acids, contributing to its potential as a substrate for enzymatic reactions. The presence of the 7-amido-4-methylcoumarin moiety indicates that it may be used in fluorescence-based assays, as this group can emit fluorescence upon cleavage by proteolytic enzymes. The peptide's sequence, comprising glycine, proline, and leucine, suggests it may have unique interactions with biological systems, potentially influencing its stability and reactivity. Additionally, the compound's solubility, stability under physiological conditions, and specific interactions with enzymes or receptors can be critical for its applications in research, particularly in studying proteolytic activity or as a tool in drug development. Overall, this compound represents a valuable asset in biochemical research and therapeutic applications.

Formula: C₃₄H₄₄N₆O₁₀

InChI: InChI=1/C34H44N6O10/c1-19(2)14-23(38-34(49)25-7-5-13-40(25)28(42)17-35-27(41)10-11-30(44)45)32(47)36-18-29(43)39-12-4-6-24(39)33(48)37-21-8-9-22-20(3)15-31(46)50-26(22)16-21/h8-9,15-16,19,23-25H,4-7,10-14,17-18H2,1-3H3,(H,35,41)(H,36,47)(H,37,48)(H,38,49)(H,44,45)/t23-,24-,25-/m0/s1

SMILES: CC(C)C[C@@H](C(=NCC(=O)N1CCC[C@H]1C(=Nc1ccc2c(C)cc(=O)oc2c1)O)O)N=C([C@@H]1CCCN1C(=O)CN=C(CCC(=O)O)O)O

Synonyms:

• Suc-Gly-Pro-Leu-Gly-Pro-AMC
• N-(3-carboxypropanoyl)glycyl-L-prolyl-L-leucylglycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-prolinamide

Suc-Gly-Pro-Leu-Gly-Pro-AMC

CAS: 72698-36-3

Suc-GPLGP-AMC, a highly sensitive, fluorogenic substrate for thimet oligopeptidase (collagenase-like peptidase, Pz-peptidase, metalloendopeptidase 24.15) as well as for post-proline cleaving enzyme (prolyl endopeptidase).

Formula: C₃₄H₄₄N₆O₁₀

Purity: 98.1%

Color and Shape: White

Molecular weight: 696.76

Ref: 01-4003958

Suc-Gly-Pro-Leu-Gly-Pro-AMC

CAS: 72698-36-3

Suc-Gly-Pro-Leu-Gly-Pro-AMC (SGLP) is a synthetic substrate that is hydrolyzed by proteases and has been used as a model substrate in protease studies. It has been shown to be cleaved by a number of enzymes, including chymotrypsin, trypsin, elastase, and cathepsin D. The hydrolysis products are sucrose glycolate, glycerol phosphate, leucine amino acid ester, and proline amino acid ester. SGLP has been shown to have low bioavailability in human liver cells and heart tissue. Studies have also shown that SGLP can stimulate the production of myelocytic cells in vitro. This activity may be due to its ability to act as an immunomodulator or by targeting tissue enzyme activities.

Formula: C₃₄H₄₄N₆O₁₀

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 696.75 g/mol

Ref: 3D-FS110526

Suc-Gly-Pro-Leu-Gly-Pro-AMC

CAS: 72698-36-3

Suc-Gly-Pro-Leu-Gly-Pro-AMC is a high purity, monoclonal antibody that can be used as a research tool or as an inhibitor. It has been shown to inhibit ion channels and protein interactions. Suc-Gly-Pro-Leu-Gly-Pro-AMC is also known as a ligand for the receptor. It has been shown to activate the receptor and cause a change in the cell membrane permeability by increasing calcium flux, which leads to an increase in intracellular calcium levels. Suc-Gly-Pro-Leu-Gly-Pro-AMC is found in Cell Biology and Pharmacology research studies.

Formula: C₃₄H₄₄N₆O₁₀

Purity: Min. 95%

Molecular weight: 696.75 g/mol

Ref: 3D-MGP-3108-V