CAS 72702-95-5

Ponalrestat

Description:

Ponalrestat, with the CAS number 72702-95-5, is a chemical compound primarily known for its role as an aldose reductase inhibitor. This substance is utilized in the management of diabetic complications, particularly in preventing the progression of diabetic neuropathy and retinopathy. Ponalrestat functions by inhibiting the enzyme aldose reductase, which is involved in the conversion of glucose to sorbitol, thereby reducing osmotic and oxidative stress in cells. The compound is typically characterized by its moderate solubility in water and its ability to interact with biological systems, making it a subject of interest in pharmacological research. Its chemical structure includes functional groups that contribute to its inhibitory activity, and it is often studied for its potential therapeutic benefits in diabetes-related conditions. As with many pharmacological agents, the safety profile, dosage, and potential side effects are critical considerations in its application. Overall, Ponalrestat represents a significant focus in the development of treatments aimed at mitigating the complications associated with diabetes.

Formula: C₁₇H₁₂BrFN₂O₃

InChI: InChI=1/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)

SMILES: c1ccc2c(c1)c(CC(=O)O)nn(Cc1ccc(cc1F)Br)c2=O

Synonyms:

• Ponalrestat [USAN:INN:BAN]
• 1-Phthalazineacetic acid, 3-((4-bromo-2-fluorophenyl)methyl)-3,4-dihydro-4-oxo-
• 3-(4-Bromo-2-fluorobenzyl)-3,4-dihydro-4-oxo-1-phthalazineacetic acid
• Ici 128,436
• Ponalrestatum
• Ponalrestatum [Latin]
• Unii-2Cv0A5G64E
• [3-(4-Bromo-2-Fluorobenzyl)-4-Oxo-3,4-Dihydrophthalazin-1-Yl]Acetic Acid

1-Phthalazineaceticacid, 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-

CAS: 72702-95-5

Formula: C₁₇H₁₂BrFN₂O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 391.1912

Ref: IN-DA005PTL

2-(3-(4-Bromo-2-Fluorobenzyl)-4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetic Acid

CAS: 72702-95-5

2-(3-(4-Bromo-2-Fluorobenzyl)-4-Oxo-3,4-Dihydrophthalazin-1-Yl)Acetic Acid

Purity: 98%

Molecular weight: 391.19g/mol

Ref: 54-PC108695

Ponalrestat

CAS: 72702-95-5

Ponalrestat

Purity: ≥95%

Molecular weight: 391.19g/mol

Ref: 54-BUP06837

Ponalrestat

CAS: 72702-95-5

Ponalrestat is an aldose reductase inhibitor.

Formula: C₁₇H₁₂BrFN₂O₃

Purity: 97.34% - 99.86%

Color and Shape: Solid

Molecular weight: 391.19

Ref: TM-T2013

Ponalrestat

CAS: 72702-95-5

Ponalrestat is an aldose reductase inhibitor, which is a synthetic compound developed for pharmacological purposes. It originates from chemical synthesis designed to target and inhibit the enzyme aldose reductase effectively. The mode of action involves the competitive inhibition of aldose reductase, an enzyme involved in the polyol pathway of glucose metabolism. By preventing the reduction of glucose to sorbitol, it reduces sorbitol accumulation associated with diabetic complications.

Formula: C₁₇H₁₂BrFN₂O₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 391.19 g/mol

Ref: 3D-FP102755

Ponalrestat - Bio-X ™

CAS: 72702-95-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₇H₁₂BrFN₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 391.19 g/mol

Ref: 3D-BP300109

2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

CAS: 72702-95-5

Purity: ≥95%

Molecular weight: 391.1960144

Ref: 10-F869052