CAS 72732-56-0

Piritrexim

Description:

Piritrexim is a synthetic compound classified as an antimetabolite, primarily used in the treatment of certain types of cancer and as an antimicrobial agent. It is known for its structural similarity to folic acid, which allows it to interfere with the synthesis of nucleic acids by inhibiting dihydrofolate reductase, an enzyme critical for DNA replication and cell division. This mechanism makes Piritrexim effective against rapidly dividing cells, such as those found in tumors and some pathogens. The compound is typically administered in a clinical setting, and its pharmacokinetics can vary based on the formulation and route of administration. Piritrexim has been studied for its potential in treating various malignancies and infections, although its use may be limited by side effects and the development of resistance in some cases. As with many antimetabolites, careful monitoring of patients is essential to manage toxicity and ensure therapeutic efficacy.

Formula: C₁₇H₁₉N₅O₂

InChI: InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22)

InChI key: InChIKey=VJXSSYDSOJBUAV-UHFFFAOYSA-N

SMILES: CC=1C2=C(N=CC1CC3=C(OC)C=CC(OC)=C3)N=C(N)N=C2N

Synonyms:

• NSC 351521
• Piritrexim
• 6-[(2,5-Dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
• Pyrido[2,3-d]pyrimidine-2,4-diamine, 6-[(2,5-dimethoxyphenyl)methyl]-5-methyl-
• BW 301U

piritrexim

CAS: 72732-56-0

Formula: C₁₇H₁₉N₅O₂

Purity: 95%

Molecular weight: 325.3651

Ref: IN-DA00FFIU

Piritrexim

CAS: 72732-56-0

Piritrexim

Purity: ≥98%

Molecular weight: 325.37g/mol

Ref: 54-BUP02234

Piritrexim

CAS: 72732-56-0

Piritrexim is a drug that inhibits the synthesis of purines, which are important for the production of DNA and RNA. This drug has been shown to have inhibitory properties against hl-60 cells. Piritrexim binds to the target enzymes involved in the synthesis of purines, including dihydropyrimidine dehydrogenase and xanthine oxidase, and forms covalent linkages with these proteins. The structure of piritrexim has been elucidated by means of nuclear magnetic resonance spectroscopy (NMR) and mass spectroscopy (MS). Piritrexim has also been shown to have anti-cancer activity in mice when combined with interferon alpha-2b.

Formula: C₁₇H₁₉N₅O₂

Purity: Min. 95%

Molecular weight: 325.4 g/mol

Ref: 3D-XCA73256

Piritrexim

CAS: 72732-56-0

Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma

Formula: C₁₇H₁₉N₅O₂

Purity: 98.50% - >99.99%

Color and Shape: Solid

Molecular weight: 325.37

Ref: TM-T24644