CAS 72795-19-8

rel-(2R,3S)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol

Description:

The chemical substance known as rel-(2R,3S)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol, with the CAS number 72795-19-8, is a chiral compound characterized by its specific stereochemistry at the 2 and 3 positions of the butanol backbone. This compound features a dihydroindene moiety, which contributes to its hydrophobic characteristics and potential biological activity. The presence of an isopropylamino group enhances its solubility and may influence its pharmacological properties. As a tertiary alcohol, it can participate in various chemical reactions, including oxidation and esterification. The stereochemistry is crucial for its interaction with biological targets, potentially affecting its efficacy and safety profile in pharmaceutical applications. Overall, this compound's unique structure suggests it may have specific applications in medicinal chemistry, particularly in the development of drugs targeting neurological or cardiovascular systems. Further studies would be necessary to fully elucidate its properties and potential uses.

Formula: C₁₇H₂₇NO₂

InChI: InChI=1/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/s2

InChI key: InChIKey=VFIDUCMKNJIJTO-AYSIPDSENA-N

SMILES: O(C[C@@H]([C@@H](NC(C)C)C)O)C1=C2C(=C(C)C=C1)CCC2

Synonyms:

• (2R,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol
• (R*,S*)-(±)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol
• 1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol hydrochloride (1:1)
• 2-Butanol, 1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-, (2R,3S)-rel-
• 2-Butanol, 1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-, (R*,S*)-
• Ci 118,551
• ICI-118551 HCl
• Ici-118551
• rel-(2R,3S)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol

ICI 118,551 hydrochloride

CAS: 72795-19-8

Formula: C₁₇H₂₇NO₂·HCl

Molecular weight: 313.86

Ref: 7W-GL4970

ICI-118551

CAS: 72795-19-8

Formula: C₁₇H₂₇NO₂

Molecular weight: 277.41

Ref: 4Z-I-149001

Ici 118551 hydrochloride

CAS: 72795-19-8

Ici 118551 is a low potency, non-steroidal, androgen receptor antagonist. It has been shown to inhibit the proliferation of human prostate cancer cells by binding to the androgen receptor. Ici 118551 also inhibits cardiac hypertrophy in rats, which may be due to its ability to block the effects of angiotensin II. The drug also blocks the effects of 2-adrenergic receptors in the heart muscle and papillary muscles, reducing cytosolic Ca2+ levels. Ici 118551 also has a strong effect on Toll-like receptor 4 (TLR4) signalling pathways in mouse models of sepsis, which may be due to its ability to reduce proinflammatory cytokines (IL-1β) and prevent activation of NF-κB.

Formula: C₁₇H₂₇NO₂

Purity: Min. 95%

Molecular weight: 277.4 g/mol

Ref: 3D-XCA79519