CAS 72797-41-2

Tianeptine

Description:

Tianeptine is an atypical antidepressant primarily used in the treatment of major depressive disorder and anxiety. It is classified as a selective serotonin reuptake enhancer (SSRE), which distinguishes it from traditional SSRIs that inhibit serotonin reuptake. Tianeptine's mechanism of action involves modulating glutamate receptors and enhancing neuroplasticity, which may contribute to its antidepressant effects. The substance is known for its unique pharmacological profile, including potential anxiolytic and neuroprotective properties. Tianeptine is typically administered in oral form and has a relatively short half-life, necessitating multiple doses throughout the day for sustained effects. It is important to note that while tianeptine is approved in some countries, it is not universally recognized or available, and its use can be associated with dependence and withdrawal symptoms. As with any medication, it is crucial to use tianeptine under medical supervision to monitor for potential side effects and interactions with other substances.

Formula: C₂₁H₂₅ClN₂O₄S

InChI: InChI=1S/C21H25ClN2O4S/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26)

InChI key: InChIKey=JICJBGPOMZQUBB-UHFFFAOYSA-N

SMILES: N(CCCCCCC(O)=O)C1C=2C(S(=O)(=O)N(C)C=3C1=CC=CC3)=CC(Cl)=CC2

Synonyms:

• (1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide
• 7-[(3-Chloro-6,11-Dihydro-6-Methyldibenzo[C,F][1,2]Thiazepin-11-Yl)-Amino]Heptanoic Acid S,S-Dioxide
• 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid
• 7-[(3-Chloro-6-Methyl-5,5-Dioxido-6,11-Dihydrodibenzo[C,F][1,2]Thiazepin-11-Yl)Amino]Heptanoic Acid
• Coaxil
• Dibenzo[c,f][1,2]thiazepine, heptanoic acid deriv.
• Heptanoic Acid, 7-[(3-Chloro-6,11-Dihydro-6-Methyl-5,5-Dioxidodibenzo[C,F][1,2]Thiazepin-11-Yl)Amino]-
• Heptanoic acid, 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]-, S,S-dioxide, (±)-
• Tianeptine acid
• Tianeptine

Tianeptine Sodium Salt

CAS: 30123-17-2, 72797-41-2

Formula: C₂₁H₂₄ClN₂NaO₄S

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 458.93

Ref: 3B-T3131

Tianeptine

CAS: 72797-41-2

Formula: C₂₁H₂₅ClN₂O₄S

Molecular weight: 436.95

Ref: 7W-GP0078

Tianeptine

CAS: 72797-41-2

Tianeptine (Tianeptine sodium) 是一种选择性5-HT 摄取促进剂，具有抗抑郁、抗焦虑和神经保护作用，可用于缓解疼痛的研究。

Formula: C₂₁H₂₅ClN₂O₄S

Purity: 99.04%

Color and Shape: Solid

Molecular weight: 436.95

Ref: TM-T8140

Tianeptine

CAS: 72797-41-2

Applications Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.
References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),

Formula: C₂₁H₂₅ClN₂O₄S

Color and Shape: White To Off-White

Molecular weight: 436.95

Ref: TR-T436800

Tianeptine-d4 (Major)

Controlled Product

CAS: 72797-41-2

Stability Hygroscopic
Applications Tianeptine-d4 (Major) is the labeled analogue of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.
References Malen, C., et al.: Experientia, 28, 811 (1972); Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987); Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990); Pierre, A., et a.: Cancer Res., 51, 2312 (1991)

Formula: C₂₁H₂₁D₄ClN₂O₄S

Color and Shape: Neat

Molecular weight: 440.98

Ref: TR-T436803

(S)-Tianeptine

Controlled Product

CAS: 72797-41-2

Formula: C₂₁H₂₅ClN₂O₄S

Color and Shape: Neat

Molecular weight: 436.952

Ref: TR-T436835

Tianeptine

Controlled Product

CAS: 72797-41-2

Full agonist of the μ-opioid receptor (MOR) with Ki of 383 nM. It also weakly agonizes the δ-opioid receptor (DOR) with a Ki >10 μM. Tianeptine has antidepressant effects but can also regulate neuroplasticity in the amygdala and stress-induced release of glutamate. It can generate analgesia and reward, typical opiate-like behavioural effects, but does not induce tolerance or withdrawal.

Formula: C₂₁H₂₅ClN₂O₄S

Purity: Min. 95%

Molecular weight: 436.95 g/mol

Ref: 3D-FT28263