CAS 7280-77-5

Cyclo(L-Phe-L-Leu)

Description:

Cyclo(L-Phe-L-Leu), also known as cyclo(phenylalanine-leucine), is a cyclic dipeptide composed of the amino acids phenylalanine (Phe) and leucine (Leu). This compound features a cyclic structure formed by the peptide bond between the carboxyl group of one amino acid and the amino group of the other, resulting in a stable ring formation. Cyclo(L-Phe-L-Leu) exhibits characteristics typical of peptides, including potential biological activity and the ability to interact with various receptors in biological systems. Its cyclic nature often enhances stability against enzymatic degradation compared to linear peptides. The presence of the aromatic phenylalanine side chain contributes to hydrophobic interactions, while the leucine side chain adds to the overall hydrophobic character of the molecule. This dipeptide may be of interest in pharmaceutical research due to its potential roles in signaling pathways and as a building block for more complex peptide structures. Additionally, its unique properties can be exploited in drug design and development, particularly in the context of peptide-based therapeutics.

Formula: C₁₅H₂₀N₂O₂

InChI: InChI=1S/C15H20N2O2/c1-10(2)8-12-14(18)17-13(15(19)16-12)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9H2,1-2H3,(H,16,19)(H,17,18)/t12-,13-/m0/s1

InChI key: InChIKey=QPDMOMIYLJMOQJ-STQMWFEESA-N

SMILES: C([C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1)C2=CC=CC=C2

Synonyms:

• (3S,6S)-3-(2-Methylpropyl)-6-(phenylmethyl)-2,5-piperazinedione
• (3S,6S)-3-Benzyl-6-isobutylpiperazine-2,5-dione
• 2,5-Piperazinedione, 3-(2-Methylpropyl)-6-(Phenylmethyl)-
• 2,5-Piperazinedione, 3-(2-methylpropyl)-6-(phenylmethyl)-, (3S,6S)-
• 2,5-Piperazinedione, 3-(2-methylpropyl)-6-(phenylmethyl)-, (3S-cis)-
• 2,5-Piperazinedione, 3-benzyl-6-isobutyl-, (3S,6S)-
• 3-Benzyl-6-isobutyl-2,5-dioxopiperazine
• 3-Benzyl-6-isobutylpiperazine-2,5-dione
• <span class="text-smallcaps">L</smallcap>-Phenylalanyl-<smallcap>L</span>-leucine diketopiperazine
• Cyclo(<span class="text-smallcaps">L</smallcap>-Leu-<smallcap>L</span>-Phe)
• Cyclo(<span class="text-smallcaps">L</smallcap>-Phe-<smallcap>L</span>-Leu)
• Cyclo(<span class="text-smallcaps">L</smallcap>-leucyl-<smallcap>L</span>-phenylalanyl)
• Cyclo(Leucyl-Phenylalanyl)
• Cyclo-<span class="text-smallcaps">L</smallcap>-leucyl-<smallcap>L</span>-phenylalanine

Cyclo(-Leu-Phe)

CAS: 7280-77-5

This diketopiperazine is converted into the antibacterial dehydropeptide albonoursin by cyclo(Leu-Phe) oxidase from S. albulus KO-23.

Formula: C₁₅H₂₀N₂O₂

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 260.34

Ref: 01-4025585

Cyclo(-leu-phe)

CAS: 7280-77-5

Formula: C₁₅H₂₀N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 260.3315

Ref: IN-DA0061O7

Cyclo(-L-Leu-L-Phe)

CAS: 7280-77-5

Cyclo(-L-Leu-L-Phe) is a nonribosomal peptide that inhibits bacterial growth. It is synthesized from the amino acids L-leucine, L-phenylalanine, and L-tyrosine. The antibacterial activity of this compound was tested in fibroblast cells and human lung tissue. Cyclo(-L-Leu-L-Phe) showed no cytotoxicity in these cell lines at concentrations up to 10 µg/mL. Cyclo(-L-Leu-L-Phe) also has antimicrobial activity against Streptomyces lividans and other bacteria. Cyclo(-L-Leu-L-Phe) can be detected by high performance liquid chromatography (HPLC).

Formula: C₁₅H₂₀N₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 260.33 g/mol

Ref: 3D-FC49434

Cyclo(-L-Leu-L-Phe)

CAS: 7280-77-5

Formula: C₁₅H₂₀N₂O₂

Purity: ≥98%

Molecular weight: 260.337

Ref: 10-F493185

Cyclo(L-Leu-L-Phe)

Controlled Product

CAS: 7280-77-5

Formula: C₁₅H₂₀N₂O₂

Color and Shape: Neat

Molecular weight: 260.332

Ref: TR-C989755