CAS 72803-02-2

Darodipine

Description:

Darodipine is a chemical compound classified as a calcium channel blocker, primarily used in the treatment of hypertension and certain cardiovascular conditions. It functions by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. The compound is characterized by its ability to selectively target these channels, which helps in managing blood flow and reducing the workload on the heart. Darodipine is typically administered in oral form and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics include good absorption and metabolism, primarily in the liver. Side effects may include dizziness, headache, and peripheral edema, which are common with calcium channel blockers. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, Darodipine represents a valuable option in the pharmacological management of hypertension, contributing to improved cardiovascular health.

Formula: C₁₉H₂₁N₃O₅

InChI: InChI=1S/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3

InChI key: InChIKey=QERUYFVNIOLCHV-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1C(C(C(OCC)=O)=C(C)NC1C)C=2C=3C(C=CC2)=NON3

Synonyms:

• 2,1,3-Benzoxadiazole, 3,5-pyridinedicarboxylic acid deriv.
• 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, diethyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester
• Darodipine [USAN:INN]
• Darodipino
• Darodipino [Spanish]
• Darodipinum
• Darodipinum [Latin]
• Dazodipin
• Diethyl 4-(2,1,3-Benzoxadiazol-4-Yl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate
• Diethyl 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• Py 108-068
• Py 108068

Darodipine

CAS: 72803-02-2

Darodipine

Purity: ≥98%

Molecular weight: 371.39g/mol

Ref: 54-BUP03996

Darodipine

Controlled Product

CAS: 72803-02-2

Applications Darodipine, is a calcium channel antagonist.
References Matucci, R., et al.: British J. Pharmacol., 122, 1353 (1997);

Formula: C₁₉H₂₁N₃O₅

Color and Shape: Neat

Molecular weight: 371.39

Ref: TR-D193450

Darodipine

CAS: 72803-02-2

Darodipine is a calcium channel blocker, which is derived from dihydropyridine compounds. Its primary mode of action involves the inhibition of voltage-gated calcium channels in the smooth muscle cells of the vascular system. By preventing calcium influx, Darodipine leads to reduced contraction of the vascular smooth muscle, resulting in vasodilation and decreased vascular resistance.

Formula: C₁₉H₂₁N₃O₅

Purity: Min. 95%

Molecular weight: 371.4 g/mol

Ref: 3D-XCA80302

Darodipine

CAS: 72803-02-2

Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.

Formula: C₁₉H₂₁N₃O₅

Purity: 99.67%

Color and Shape: Solid

Molecular weight: 371.39

Ref: TM-T15053