CAS 72810-61-8

4-(m-tolyl)-1,1-dioxo-pyrido[4,3-e][1,2,4]thiadiazin-3-one

Description:

4-(m-Tolyl)-1,1-dioxo-pyrido[4,3-e][1,2,4]thiadiazin-3-one, with the CAS number 72810-61-8, is a heterocyclic compound characterized by its complex structure that includes a pyridine ring fused with a thiadiazine moiety. This compound features a dioxo functional group, which contributes to its reactivity and potential applications in various chemical reactions. The presence of the m-tolyl group indicates that there is a methyl group attached to the aromatic ring, influencing the compound's electronic properties and steric hindrance. Typically, such compounds exhibit biological activity, making them of interest in pharmaceutical research. They may also possess unique optical and electronic properties due to their conjugated system. The stability and solubility of this compound can vary based on the solvent and environmental conditions, which is crucial for its application in synthesis and potential medicinal uses. Overall, 4-(m-tolyl)-1,1-dioxo-pyrido[4,3-e][1,2,4]thiadiazin-3-one represents a significant class of compounds in organic and medicinal chemistry.

Formula: C₁₃H₁₁N₃O₃S

InChI: InChI=1/C13H11N3O3S/c1-9-3-2-4-10(7-9)16-11-5-6-14-8-12(11)20(18,19)15-13(16)17/h2-8H,1H3,(H,15,17)

SMILES: Cc1cccc(c1)N1c2ccncc2S(=O)(=O)N=C1O

Torsemide Related Compound E (4-(3-Tolyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide)

CAS: 72810-61-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₃H₁₁N₃O₃S

Color and Shape: White Powder

Molecular weight: 289.05211

Ref: 45-1672359

Torasemide (Torsemide) EP Impurity A (Torasemide (Torsemide) USP Related Compound E)

CAS: 72810-61-8

Formula: C₁₃H₁₁N₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 289.31

Ref: 4Z-T-116

4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide

CAS: 72810-61-8

Color and Shape: Neat

Ref: 86-MM1283.01

Torasemide EP Impurity A

CAS: 72810-61-8

Formula: C₁₃H₁₁N₃O₃S

Molecular weight: 289.31

Ref: ST-EA-CP-T27001

4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide Hydrlochloride

Controlled Product

CAS: 72810-61-8

Stability Hygroscopic
Applications 4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide Hydrlochloride is an impurity in the synthesis of Torsemide (T548750), a a diuretic agent.
References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),

Formula: C₁₃H₁₂ClN₃O₃S

Color and Shape: Neat

Molecular weight: 325.77

Ref: TR-M327370

4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide Sodium Salt

CAS: 72810-61-8

Stability Hygroscopic
Applications An impurity of Torsemide.

Formula: C₁₃H₁₁N₃O₃S

Color and Shape: Off-White To Light Yellow

Molecular weight: 311.29

Ref: TR-M325901

Torsemide impurity A

CAS: 72810-61-8

Torsemide impurity A (T-A) is a photolytic impurity that has been detected in the drug product. The photolytic reactions of T-A are linear with respect to the concentration of torsades de pointes. The chromatographic method used to detect T-A was validated and found to be accurate within 10% relative standard deviation. This validation was performed using a calibration curve obtained using a chromatographic method and elution time. The validation study also showed that the linearity of the calibration curve resulted in an accurate measurement of drug concentration.

Formula: C₁₃H₁₁N₃O₃S

Purity: Min. 95%

Molecular weight: 289.31 g/mol

Ref: 3D-FT159524