CAS 72956-44-6

2-(2-{[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino}ethoxy)phenol

Description:

2-(2-{[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino}ethoxy)phenol, with the CAS number 72956-44-6, is a complex organic compound characterized by its multi-functional structure. It features a carbazole moiety, which is known for its aromatic properties and potential applications in organic electronics and photonics. The presence of a phenolic group contributes to its potential as an antioxidant and its ability to form hydrogen bonds, enhancing solubility in various solvents. The compound also contains an ether linkage and an amino group, which may impart additional reactivity and influence its biological activity. Its hydroxyl groups suggest potential for interactions with biological systems, making it of interest in medicinal chemistry. Overall, this compound's unique structural features may lead to diverse applications in fields such as pharmaceuticals, materials science, and organic synthesis, although specific properties like solubility, melting point, and reactivity would require empirical measurement for precise characterization.

Formula: C₂₃H₂₄N₂O₄

InChI: InChI=1/C23H24N2O4/c26-16(14-24-12-13-28-21-10-4-3-9-20(21)27)15-29-22-11-5-8-19-23(22)17-6-1-2-7-18(17)25-19/h1-11,16,24-27H,12-15H2

SMILES: c1ccc2c(c1)c1c(cccc1OCC(CNCCOc1ccccc1O)O)[nH]2

Synonyms:

• Phenol, 2-(2-((3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)amino)ethoxy)-

O-Desmethylcarvedilol

CAS: 72956-44-6

O-Desmethylcarvedilol

Purity: 98%

Molecular weight: 392.45g/mol

Ref: 54-OR1075408

O-Desmethylcarvedilol

CAS: 72956-44-6

O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 µM). Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 µg/kg).

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Solid

Molecular weight: 392.45

Ref: TM-T203083

O-Desmethyl Carvedilol

CAS: 72956-44-6

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Off-White To Gray Solid

Molecular weight: 392.46

Ref: 4Z-C-023

O-Desmethyl Carvedilol

Controlled Product

CAS: 72956-44-6

Applications A metabolite of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity.
References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Neat

Molecular weight: 392.45

Ref: TR-D291475

O-Desmethyl Carvedilol

CAS: 72956-44-6

Formula: C₂₃H₂₄N₂O₄

Molecular weight: 392.46

Ref: ST-EA-CP-C10036