CAS 7298-73-9

Methylphenacetin

Description:

Methylphenacetin, with the CAS number 7298-73-9, is an organic compound that belongs to the class of analgesics and antipyretics. It is a derivative of phenacetin, characterized by the presence of a methyl group attached to the nitrogen atom of the acetanilide structure. Methylphenacetin is typically a white to off-white crystalline powder, and it is known for its moderate analgesic and antipyretic properties, making it useful in pain relief and fever reduction. The compound is soluble in organic solvents such as ethanol and chloroform but has limited solubility in water. Its mechanism of action is believed to involve the inhibition of prostaglandin synthesis, similar to other non-opioid analgesics. However, due to safety concerns, including potential nephrotoxicity and the risk of methemoglobinemia, its use has declined in favor of safer alternatives. Methylphenacetin is not widely used in many countries today, and its regulatory status may vary, reflecting ongoing concerns about its safety profile.

Formula: C₁₁H₁₅NO₂

InChI: InChI=1S/C11H15NO2/c1-4-14-11-7-5-10(6-8-11)12(3)9(2)13/h5-8H,4H2,1-3H3

InChI key: InChIKey=LLYKXHAEYFJRQZ-UHFFFAOYSA-N

SMILES: N(C(C)=O)(C)C1=CC=C(OCC)C=C1

Synonyms:

• Acetamide, N-(4-ethoxyphenyl)-N-methyl-
• p-Acetophenetidide, N-methyl-
• N-(4-Ethoxyphenyl)-N-methylacetamide
• N-Methylphenacetin
• Methylphenacetin