CAS 73-04-1

3′-Deoxyadenosine 5′-(tetrahydrogen triphosphate)

Description:

3′-Deoxyadenosine 5′-(tetrahydrogen triphosphate), commonly referred to as dATP, is a nucleotide that plays a crucial role in cellular metabolism and biochemistry. It is a derivative of adenosine triphosphate (ATP) but lacks the hydroxyl group at the 3′ position of the ribose sugar, which distinguishes it as a deoxynucleotide. This structural modification makes dATP essential for DNA synthesis, as it serves as a substrate for DNA polymerases during replication and repair processes. The molecule consists of a nitrogenous base (adenine), a deoxyribose sugar, and a triphosphate group, which provides the energy necessary for various biochemical reactions. dATP is also involved in signaling pathways and can act as a cofactor in enzymatic reactions. Its CAS number, 73-04-1, is a unique identifier that facilitates the cataloging and referencing of this compound in scientific literature and databases. Overall, dATP is vital for maintaining the integrity and functionality of genetic material in living organisms.

Formula: C₁₀H₁₆N₅O₁₂P₃

InChI: InChI=1S/C10H16N5O12P3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,10+/m0/s1

InChI key: InChIKey=NLIHPCYXRYQPSD-BAJZRUMYSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)C1

Synonyms:

• 3'-Deoxy ATP
• 3′-Deoxyadenosine 5′-triphosphate
• 3′-Deoxyadenosine triphosphate
• 3′-Deoxyribofuranosyladenine 5′-triphosphate
• 73-04-1
• Adenosine 5′-(tetrahydrogen triphosphate), 3′-deoxy-
• Adenosine, 3′-deoxy-, 5′-(tetrahydrogen triphosphate)
• Adenosine, 3′-deoxy-, 5′-triphosphate
• Cordycepin, triphosphate
• Cordycepin-5'-triphosphate
• Nqz-034
• 3′-Deoxyadenosine 5′-(tetrahydrogen triphosphate)
• 3'-Deoxyadenosine-5'-(tetrahydrogen Triphosphate)

3'-Deoxyadenosine-5'-triphosphate sodium salt - 10mM aqueous solution

CAS: 73-04-1

3'-Deoxyadenosine-5'-triphosphate sodium salt is a nucleotide that has been shown to be effective in chemotherapy. It is a substrate for the synthesis of DNA, RNA, and ATP. 3'-Deoxyadenosine-5'-triphosphate sodium salt is also a building block for DNA polymerase, which is an enzyme that synthesizes DNA from a template. It has been shown to have anticancer activity in drug-resistant cells and can be used as an alternative to purine analogs such as 6-mercaptopurine or cladribine. 3'-Deoxyadenosine-5'-triphosphate sodium salt has been shown to inhibit the production of nucleotides by blocking their conversion into triphosphates, which are necessary for DNA replication and repair. This inhibition leads to apoptosis in cells with high levels of nucleotide turnover such as cardiac and myeloid cells. The drug interactions may depend on the

Formula: C₁₀H₁₆N₅O₁₂P₃

Purity: Min. 95%

Color and Shape: Colorless Powder

Molecular weight: 491.18 g/mol

Ref: 3D-ND71670