CAS 73-49-4

Quinethazone

Description:

Quinethazone is a synthetic compound classified as a thiazide diuretic, primarily used in the treatment of hypertension and edema. Its chemical structure features a thiazide ring, which is characteristic of this class of diuretics, contributing to its mechanism of action by inhibiting sodium reabsorption in the kidneys. This results in increased urine output and decreased blood volume, effectively lowering blood pressure. Quinethazone is typically administered orally and is known for its moderate potency compared to other thiazide diuretics. The substance is generally well-absorbed in the gastrointestinal tract, with its pharmacokinetics influenced by factors such as dosage and individual patient metabolism. Common side effects may include electrolyte imbalances, particularly hypokalemia, as well as potential allergic reactions. Due to its diuretic properties, Quinethazone may also be used in managing conditions related to fluid retention. As with any medication, it is essential to use Quinethazone under medical supervision to monitor for efficacy and adverse effects.

Formula: C₁₀H₁₂ClN₃O₃S

InChI: InChI=1/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)

InChI key: InChIKey=AGMMTXLNIQSRCG-UHFFFAOYSA-N

SMILES: O=C1C=2C(NC(CC)N1)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• 2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxoquinazoline-6-sulfonamide
• 2-Ethyl-7-chloro-2,3-dihydro-4(1H)-quinazolone-6-sulfonamide
• 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide
• 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline
• 7-Chloro-2-ethyl-2,3-dihydro-4-oxo-(1H)-quinazoline-6-sulfonamide
• 7-Chloro-2-ethyl-6-sulfamyl-1,2,3,4-tetrahydro-4-quinazolinone
• Aquamox
• Cl 36010
• Hydromox
• Idrokin
• Quimethazin
• Quinetazona
• Quinethazon
• Quinethazone
• Quinethazonum
• 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
• 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxoquinazoline-6-sulphonamide
• 6-Quinazolinesulfonamide, 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-
• 7-chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone
• 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
• 7-chloro-2-ethyl-4-keto-2,3-dihydro-1H-quinazoline-6-sulfonamide
• 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamid
• 2-Ethyl-7-chloro-6-sulfamoyl-1,2-dihydroquinazoline-4(3H)-one
• cl36010
• 1,2,3,4-tetrahydro-7-chloro-2-ethyl-4-oxo-6-quinazolinesulfonamid

Quinethazone

CAS: 73-49-4

Color and Shape: Neat

Ref: 61-FOR1879.00

Quinethazone

Controlled Product

CAS: 73-49-4

Applications Quinethazone is a thiazide diuretic used to treat hypertension.
References DeLuca, F.M.: Sett. Med., 54, 747 (1966); Dettli, L. et al.: Ann. N.Y. Acad. Sci., 139, 471 (1966);

Formula: C₁₀H₁₂ClN₃O₃S

Color and Shape: Neat

Molecular weight: 289.74

Ref: TR-Q670400

Quinethazone

CAS: 73-49-4

Quinethazone is a drug that belongs to the class of angiotensin II receptor antagonists. It is used for the treatment of hypertension and congestive heart failure. Quinethazone inhibits angiotensin II, which causes vasoconstriction, increases blood pressure, and decreases sodium excretion. The drug is also an effective inhibitor of the cardiac enzyme carbonic anhydrase and has been shown to be useful in treating diabetic neuropathy. Quinethazone has been found to have inhibitory properties against complex enzymes involved in infectious diseases such as tuberculosis and hepatitis C. This drug also regulates cardiac tissue growth by inhibiting protein genes, thereby preventing the development of cardiac hypertrophy.

Formula: C₁₀H₁₂ClN₃O₃S

Purity: Min. 95%

Molecular weight: 289.74 g/mol

Ref: 3D-AAA07349

Quinethazone

CAS: 73-49-4

Quinethazone is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.

Formula: C₁₀H₁₂ClN₃O₃S

Color and Shape: Fibrous Crystals From 50% Acetone Physical Description Fibrous Crystals Or White Powder (Ntp 1992)

Molecular weight: 289.74

Ref: TM-T34228