CAS 73220-03-8

Remoxipride hydrochloride

Description:

Remoxipride hydrochloride is an antipsychotic medication primarily used in the treatment of schizophrenia. It belongs to the class of drugs known as benzamide derivatives. The compound exhibits a high affinity for dopamine D2 receptors, which plays a crucial role in its therapeutic effects by modulating dopaminergic activity in the brain. Remoxipride is characterized by its ability to alleviate positive symptoms of schizophrenia, such as hallucinations and delusions, while having a relatively lower propensity for extrapyramidal side effects compared to other antipsychotics. The hydrochloride salt form enhances its solubility and stability, facilitating its administration. In terms of physical properties, Remoxipride hydrochloride is typically a white to off-white crystalline powder. It is important to note that, while it has shown efficacy in clinical settings, its use may be limited due to potential side effects and the availability of alternative treatments. As with any medication, it is essential to consider individual patient factors and consult healthcare professionals for appropriate use.

Formula: C₁₆H₂₃BrN₂O₃·ClH

InChI: InChI=1S/C16H23BrN2O3.ClH/c1-4-19-9-5-6-11(19)10-18-16(20)14-13(21-2)8-7-12(17)15(14)22-3;/h7-8,11H,4-6,9-10H2,1-3H3,(H,18,20);1H/t11-;/m0./s1

InChI key: InChIKey=WCPXLMIPGMFZMY-MERQFXBCSA-N

SMILES: C(NC[C@H]1N(CC)CCC1)(=O)C2=C(OC)C(Br)=CC=C2OC.Cl

Synonyms:

• Benzamide, 3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxy-, hydrochloride (1:1)
• Benzamide, 3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxy-, monohydrochloride
• (-)-FLA 731
• FLA 731, (-)-
• Benzamide, 3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxy-, monohydrochloride, (S)-

Remoxipride hydrochloride

CAS: 73220-03-8

Formula: C₁₆H₂₄BrClN₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 407.7304

Ref: IN-DA00FB6I

Remoxipride hydrochloride

CAS: 73220-03-8

Remoxipride hydrochloride

Purity: ≥98%

Molecular weight: 407.73g/mol

Ref: 54-BUP03865

(S)-Remoxipride Hydrochloride

Controlled Product

CAS: 73220-03-8

Stability Hygroscopic
Applications Specific dopamine D2-receptor antagonist. Antipsychotic.
References Ogren, S.O., et al.: Eur. J. Pharmacol., 102, 459 (1984), Dubin, A., et al.: J. Biomol. Screen., 10, 168 (2005),

Formula: C₁₆H₂₄BrClN₂O₃

Color and Shape: Neat

Molecular weight: 407.73

Ref: TR-R143700

Remoxipride hydrochloride

CAS: 73220-03-8

Dopamine (D2) receptor antagonist; antisychotic

Purity: Min. 95%

Ref: 3D-FR72041

Remoxipride hydrochloride

CAS: 73220-03-8

Remoxipride hydrochloride (Roxiam) is a selective antagonist of D2 receptor with IC50s of 1.57 μM, ＞100 μM and 42 μM for D2 receptor, D1 receptor and α1-

Formula: C₁₆H₂₄BrClN₂O₃

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 407.73

Ref: TM-T23232