CAS 73231-34-2

Florfenicol

Description:

Florfenicol is a synthetic antibiotic belonging to the phenicol class, primarily used in veterinary medicine for the treatment of bacterial infections in animals. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, making it a valuable therapeutic agent. Florfenicol functions by inhibiting bacterial protein synthesis, specifically targeting the 50S ribosomal subunit, which disrupts the production of essential proteins necessary for bacterial growth and reproduction. The substance is characterized by its relatively low toxicity in animals compared to other antibiotics, which allows for its use in food-producing animals under regulated conditions. Florfenicol is typically administered via injection or in feed formulations, and its pharmacokinetics indicate good tissue penetration, which is beneficial for treating systemic infections. However, its use is subject to strict regulations due to concerns about antibiotic resistance and potential residues in food products. Overall, florfenicol represents an important tool in veterinary medicine, balancing efficacy against bacterial infections with considerations for safety and regulatory compliance.

Formula: C₁₂H₁₄Cl₂FNO₄S

InChI: InChI=1/C12H14Cl2FNO2S/c1-19-8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)

InChI key: InChIKey=AYIRNRDRBQJXIF-NXEZZACHSA-N

SMILES: [C@@H]([C@H](NC(C(Cl)Cl)=O)CF)(O)C1=CC=C(S(C)(=O)=O)C=C1

Synonyms:

• 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
• 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
• 2,2-dichloro-N-{(1R,2S)-3-fluoro-1-hydroxy-1-[4-(methylsulfonyl)phenyl]propan-2-yl}acetamide
• 2,2-dichloro-N-{1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfanyl)phenyl]ethyl}acetamide
• Acetamide, 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-
• Acetamide, 2,2-dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-, [R-(R*,S*)]-
• Aquafen
• Aquaflor
• Flofenicol
• Flonicol
• Florfeniol
• Florgane
• Floron
• Nuflor
• Sch 25298
• Selectan
• Topazone
• Florfenicol
• [R-(R*,S*)]-2,2-DICHLORO-N-[1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL]ACETAMIDE
• Fluorothiamphenicol
• [r-(r*, r*)]-n-[1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide
• Sch-25298, Aquafen
• (r-(r*,s*))-methyleste
• 2,2-dichloro-n-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl
• 2,2-Dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide
• Acetamide, 2,2-dichloro-N-(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-4-(methylsulfonyl)phenylethyl-
• FLUPROFEN
• Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
• 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamid

Florfenicol

CAS: 73231-34-2, 76639-94-6

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 358.21

Ref: 3B-F0811

Florfenicol, 98%

CAS: 73231-34-2

A bacteriostatic antibiotic similar to chloramphenicol which inhibits bacterial protein synthesis This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar pr

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: 98%

Color and Shape: White to pale cream, Powder or crystalline powder

Molecular weight: 358.21

Ref: 02-J66995

Acetamide, 2,​2-​dichloro-​N-​[(1S,​2R)​-​1-​(fluoromethyl)​-​2-​hydroxy-​2-​[4-​(methylsulfonyl)​phenyl]​ethyl]​-

CAS: 73231-34-2

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: %

Color and Shape: Solid

Molecular weight: 358.2133

Ref: IN-DA00ICDO

Florfenicol

CAS: 73231-34-2

Florfenicol treats bovine respiratory disease and foot rot in cattle, and catfish enteric septicemia.

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: 99.22% - 99.33%

Color and Shape: White Crystalline Powder

Molecular weight: 358.21

Ref: TM-T0454L

Florfenicol

CAS: 73231-34-2

Florfenicol

Purity: 98%

Molecular weight: 358.21g/mol

Ref: 54-PC109152

Florfenicol

CAS: 73231-34-2

Formula: C₁₂H₁₄Cl₂FNO₄S

Color and Shape: White To Off-White Solid

Molecular weight: 358.22

Ref: 4Z-F-231

Florfenicol

CAS: 73231-34-2

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 358.21

Ref: 7W-GA3827

Florfenicol

Controlled Product

CAS: 73231-34-2

Formula: C₁₂H₁₄Cl₂FNO₄S

Color and Shape: Neat

Molecular weight: 358.21

Ref: 04-C13665000

Florfenicol-d5

CAS: 73231-34-2

Formula: C₁₂H₉D₅Cl₂FNO₄S

Color and Shape: White To Off-White Solid

Molecular weight: 363.24

Ref: 4Z-F-2314

Florfenicol

CAS: 73231-34-2

Applications Florfenicol is a fluorinated derivative of thiamphenicol. Florfenicol inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial.
References Kim, E and Aoki, T.: Microbiol. Immunol., 40, 665, (1996), Keyes, K.: Antimicrob. Agents Chemother., 44, 421 (2000)

Formula: C₁₂H₁₄Cl₂FNO₄S

Color and Shape: Yellow

Molecular weight: 358.21

Ref: TR-F405750

Florfenicol

CAS: 73231-34-2

Florfenicol is a broad-spectrum antibiotic that belongs to the group of florfenicol. It is used in veterinary medicine to treat bacterial infections in animals, including those caused by salmonella, streptococcus, and mycoplasma. Florfenicol has been shown to have an inhibitory effect on the growth of tetracycline-resistant bacteria. Florfenicol binds reversibly to the 23S ribosomal RNA in the 50S subunit of bacteria and inhibits protein synthesis. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme ribosome that is required for translation, inhibiting protein synthesis and cell division. The rate constant for this reaction has been determined using a combination of analytical methods, including chromatographic analysis and colloidal gold electrophoresis. Florfenicol also has anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 358.21 g/mol

Ref: 3D-FF23306

Florfenicol - Bio-X ™

CAS: 73231-34-2

Florfenicol is a broad-spectrum antibiotic used for the treatment of various bacteria infections. This drug is used in veterinary medicine and to treat animals with those infections. This drug works by inhibiting bacteria synthesis. It is a fluorinated synthetic analog of thiamphenicol.

Formula: C₁₂H₁₄Cl₂FNO₄S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 358.21 g/mol

Ref: 3D-BF166386

Florfenicol

CAS: 73231-34-2

Purity: 99+%

Molecular weight: 357

Ref: 10-F801753