CAS 73232-52-7

Methylnaltrexone bromide

Description:

Methylnaltrexone bromide is a quaternary ammonium derivative of naltrexone, primarily used as a medication to treat opioid-induced constipation, particularly in patients with advanced illness. It functions as a peripherally acting mu-opioid receptor antagonist, meaning it blocks the effects of opioids in the gastrointestinal tract without affecting pain relief in the central nervous system. This selective action helps alleviate constipation without reversing analgesia. Methylnaltrexone bromide is typically administered via subcutaneous injection and has a rapid onset of action. Its chemical structure includes a methyl group attached to the nitrogen atom of the naltrexone backbone, which enhances its solubility and pharmacokinetic properties. The substance is generally well-tolerated, with common side effects including abdominal pain, diarrhea, and nausea. Due to its specific mechanism of action, it is particularly beneficial for patients who are on chronic opioid therapy and experience constipation as a side effect. Methylnaltrexone bromide is classified as a prescription medication and should be used under medical supervision.

Formula: C₂₁H₂₆NO₄·Br

InChI: InChI=1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1

InChI key: InChIKey=IFGIYSGOEZJNBE-KNLJMPJLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2([N+](CC6CC6)(C)CC4)[H].[Br-]

Synonyms:

• (17RS)-17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-17-methyl-6- oxomorphinanium bromide
• (5Alpha)-17-(Cyclopropylmethyl)-3,14-Dihydroxy-17-Methyl-4,5-Epoxymorphinan-17-Ium-6-One Bromide
• Methylnaltrexone bromide [USAN]
• Moa-728
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide (1:1), (5α)-
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide, (5alpha)-
• Mrz 2663
• Mrz 2663Br
• N-Cyclopropylmethyl-noroxymorphone methobromide
• N-Methylnaltrexone bromide
• Naltrexone methobromide
• Naltrexone methyl bromide
• Relistor
• Unii-Rfo6Il3D3M

Methylnaltrexone Bromide

CAS: 73232-52-7

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₂₁H₂₆BrNO₄

Color and Shape: White Off-White Powder

Molecular weight: 435.10452

Ref: 45-1430735

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide

Purity: ≥98%

Molecular weight: 436.35g/mol

Ref: 54-BUP05752

Methyl Naltrexone-d3 Bromide (Mixture of Diastereomers)

CAS: 73232-52-7

Formula: C₂₁H₂₃D₃NO₄·Br

Molecular weight: 359.46 79.90

Ref: 4Z-N-0135

Methylnaltrexone Bromide

CAS: 73232-52-7

Formula: C₂₁H₂₆NO₄·Br

Molecular weight: 356.44 79.90

Ref: 4Z-N-0140

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists, acts to reverse the side effects of opioid drugs.

Formula: C₂₁H₂₆BrNO₄

Purity: 99.02%

Color and Shape: Solid

Molecular weight: 436.35

Ref: TM-T21422

N-Methyl Naltrexone-d3 Bromide

Controlled Product

CAS: 73232-52-7

Applications A labelled metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX), a selective μ-opioid receptor antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007),

Formula: C₂₁H₂₃D₃BrNO₄

Color and Shape: Neat

Molecular weight: 439.36

Ref: TR-M320352

N-Methyl Naltrexone Bromide

Controlled Product

CAS: 73232-52-7

Stability Hygroscopic
Applications A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Formula: C₂₁H₂₆BrNO₄

Color and Shape: Neat

Molecular weight: 436.35

Ref: TR-M320350

Methylnaltrexone Bromide

CAS: 73232-52-7

Formula: C₂₁H₂₆BrNO₄

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 436.35

Ref: 3B-M3504

N-Methyl naltrexone bromide

Controlled Product

CAS: 73232-52-7

N-Methyl naltrexone bromide is an opioid antagonist that binds to opioid receptors, preventing the binding of other opioid agonists. It has been shown to be effective in long-term treatment of chronic pain and may be used in combination with opioids for patients with hepatic impairment. The efficacy of N-methyl naltrexone bromide in treating constipation has not been established. This drug should not be used in patients with HIV infection because it may reduce the effectiveness of antiretroviral therapy. The pharmacokinetics and safety profile of this drug have been studied extensively, which showed no serious adverse effects. Histological analysis revealed that N-methyl naltrexone bromide did not affect epithelial mesenchymal cells or the intestinal villi.

Formula: C₂₁H₂₆BrNO₄

Purity: Min. 95%

Molecular weight: 436.34 g/mol

Ref: 3D-FM25532