CAS 733002-61-4

(3R,6R)-6-[7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carbonyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid

Description:

The chemical substance with the name "(3R,6R)-6-[7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carbonyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid" and CAS number "733002-61-4" is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as hydroxyl, carbonyl, and methoxy groups. This compound features a quinoline core, which is known for its biological activity, and a tetrahydropyran moiety that contributes to its stereochemistry and potential interactions in biological systems. The presence of fluorine and cyclopropyl groups suggests enhanced lipophilicity and possibly improved pharmacokinetic properties. Its stereochemistry, indicated by the (3R,6R) and (4aS,7aS) designations, implies specific three-dimensional arrangements that can significantly influence its biological activity and interactions with target proteins or enzymes. Overall, this compound may have potential applications in medicinal chemistry, particularly in the development of therapeutics targeting specific biological pathways.

Formula: C₂₇H₃₂FN₃O₁₀

InChI: InChI=1/C27H32FN3O10/c1-39-23-17-13(7-15(28)18(23)30-8-11-3-2-6-29-16(11)10-30)19(32)14(9-31(17)12-4-5-12)26(38)41-27-22(35)20(33)21(34)24(40-27)25(36)37/h7,9,11-12,16,20-22,24,27,29,33-35H,2-6,8,10H2,1H3,(H,36,37)/t11-,16+,20?,21+,22?,24?,27+/m0/s1

rac cis-moxifloxacin acyl-b-D-glucuronide

CAS: 733002-61-4

Ref: 7W-GC3829

Moxifloxacin Acyl Glucuronide

CAS: 733002-61-4

Formula: C₂₇H₃₂FN₃O₁₀

Color and Shape: Off-White Solid

Molecular weight: 577.56

Ref: 4Z-M-275

rac cis-Moxifloxacin Acyl-b-D-glucuronide (>85%)

Controlled Product

CAS: 733002-61-4

Applications A metabolite of Moxifloxacin (M745000).
References Steinijans, V., et al.: J. Clin. Pharmacol. Ther., 29, 323 (1991), Haria, M., et al.: Drugs, 51, 585 (1996), Pickerill, K., et al.: Pharmacotherapy, 20, 417(2000),

Formula: C₂₇H₃₂FN₃O₁₀

Purity: >85%

Color and Shape: Neat

Molecular weight: 577.56

Ref: TR-M745010

rac cis-Moxifloxacin-d4 Acyl-β-D-glucuronide

Controlled Product

CAS: 733002-61-4

Applications A labelled metabolite of Moxifloxacin (M745000).
References Steinijans, V., et al.: J. Clin. Pharmacol. Ther., 29, 323 (1991), Haria, M., et al.: Drugs, 51, 585 (1996), Pickerill, K., et al.: Pharmacotherapy, 20, 417(2000),

Formula: C₂₇H₂₈D₄FN₃O₁₀

Color and Shape: Neat

Molecular weight: 581.58

Ref: TR-M745012

rac cis-Moxifloxacin acyl-b-D-glucuronide

CAS: 733002-61-4

Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. Moxifloxacin forms an acyl-b-D-glucuronide metabolite (rac) which has a lower risk of drug resistance than moxifloxacin itself. Rac-moxifloxacin acyl-b-D-glucuronide also has a higher affinity for bacterial 16S ribosomal RNA, leading to better inhibition of protein synthesis and cell death. This drug is synthesized by modification of sugar moieties on the racemic compound with glycals to form oligosaccharides and polysaccharides. It is then methylated with a methyl group from S-adenosyl methionine (SAM). The resulting product is purified by crystallization or column chromatography to remove impurities. Rac cis

Formula: C₂₇H₃₂FN₃O₁₀

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 577.56 g/mol

Ref: 3D-MR16843