CAS 733030-01-8

Thymidine, α,α,α-trifluoro-, mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)

Description:

Thymidine, α,α,α-trifluoro-, mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1), identified by CAS number 733030-01-8, is a chemical compound that combines elements of nucleoside chemistry and pyrimidine derivatives. The presence of trifluoromethyl groups in thymidine suggests enhanced lipophilicity and potential alterations in biological activity compared to its non-fluorinated counterparts. The compound's structure indicates it may exhibit unique interactions with biological targets, potentially influencing nucleic acid synthesis or function. The inclusion of a pyrimidinedione moiety, particularly with a substituted imino-pyrrolidine, suggests potential applications in medicinal chemistry, possibly as an antiviral or anticancer agent. The hydrochloride form indicates it is a salt, which may enhance solubility and stability in aqueous environments. Overall, this compound's characteristics suggest it could be of interest in pharmaceutical research, particularly in the development of novel therapeutic agents targeting nucleic acid processes.

Formula: C₁₀H₁₁F₃N₂O₅·C₉H₁₁ClN₄O₂·ClH

InChI: InChI=1S/C10H11F3N2O5.C9H11ClN4O2.ClH/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7;10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h2,5-7,16-17H,1,3H2,(H,14,18,19);11H,1-4H2,(H2,12,13,15,16);1H/t5-,6+,7+;;/m0../s1

InChI key: InChIKey=PLIXOHWIPDGJEI-OJSHLMAWSA-N

SMILES: C(C1=C(Cl)C(=O)NC(=O)N1)N2C(=N)CCC2.Cl.O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C(F)(F)F)C(=O)N1

Synonyms:

• Thymidine, α,α,α-trifluoro-, mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)
• Thymidine, α,α,α-trifluoro-, mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride
• Trifluridine-tipiracil hydrochloride mixt.
• Lonsurf
• TAS 102

Trifluridine/tipiracil HCl mixture

CAS: 733030-01-8

Formula: C₁₉H₂₃Cl₂F₃N₆O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 575.3231

Ref: IN-DA00FFPP

Trifluridine/tipiracil hydrochloride mixture

CAS: 733030-01-8

Trifluridine/tipiracil hydrochloride mixture

Purity: ≥98%

Molecular weight: 871.53g/mol

Ref: 54-BUP15374

Trifluridine/tipiracil hydrochloride mixture

CAS: 733030-01-8

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a

Formula: C₂₉H₃₄Cl₂F₆N₈O₁₂

Purity: 98% - 99.79%

Color and Shape: Solid

Molecular weight: 871.53

Ref: TM-T3658

TAS 102 (2:1)

Controlled Product

CAS: 733030-01-8

Stability Hygroscopic
Applications TAS 102 (Tipiracil-trifluridine) is a thymidine phosphorylase inhibitor used in chemotherapy treatment of advanced/recurring colorectal cancer.
References Kimura, M. et al.: Pharmazie., 72, 49 (2017);

Formula: C₉H₁₁ClN₄O₂•HClC₁₀H₁₁F₃N₂O₅

Color and Shape: Neat

Molecular weight: [242.66 + (36.46)] + (296.20)2

Ref: TR-T007720