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CAS 73347-43-0

:

11(R)-HETE

Description:
11(R)-HETE, or 11-hydroxy-5,8,12-eicosatrienoic acid, is a bioactive lipid belonging to the family of eicosanoids, which are derived from arachidonic acid. This compound is characterized by its hydroxyl group at the 11th carbon position, which influences its biological activity and interactions within the body. It plays a significant role in various physiological processes, including inflammation and vascular function. 11(R)-HETE is known to act as a signaling molecule, participating in the modulation of cell proliferation, apoptosis, and immune responses. Its synthesis is typically catalyzed by lipoxygenases, enzymes that convert polyunsaturated fatty acids into biologically active metabolites. The compound's stereochemistry, particularly the (R) configuration, is crucial for its interaction with specific receptors and enzymes, impacting its overall efficacy and function in biological systems. Research into 11(R)-HETE continues to explore its potential therapeutic applications, particularly in the context of cardiovascular health and inflammatory diseases.
Formula:C20H32O3
InChI:InChI=1S/C20H32O3/c1-2-3-4-5-7-10-13-16-19(21)17-14-11-8-6-9-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b9-6-,10-7-,14-11-,16-13+/t19-/m0/s1
InChI key:InChIKey=GCZRCCHPLVMMJE-WXMXURGXSA-N
SMILES:[C@@H](C/C=C\C/C=C\CCCC(O)=O)(/C=C/C=C\CCCCC)O
Synonyms:
  • (5E,8Z,11R,12Z,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoic acid
  • (5Z,8Z,11R,12E,14Z)-11-Hydroxy-5,8,12,14-eicosatetraenoic acid
  • (5Z,8Z,11R,12E,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoic acid
  • 11(R)-Hete
  • 5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, (5Z,8Z,11R,12E,14Z)-
  • 5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, [R-(E,Z,Z,Z)]-
  • [11R-(5Z,8Z,12E,14Z)]-11-Hydroxy-5,8,12,14-eicosatetraenoic acid
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