CAS 73347-43-0

11(R)-HETE

Description:

11(R)-HETE, or 11-hydroxy-5,8,12-eicosatrienoic acid, is a bioactive lipid belonging to the family of eicosanoids, which are derived from arachidonic acid. This compound is characterized by its hydroxyl group at the 11th carbon position, which influences its biological activity and interactions within the body. It plays a significant role in various physiological processes, including inflammation and vascular function. 11(R)-HETE is known to act as a signaling molecule, participating in the modulation of cell proliferation, apoptosis, and immune responses. Its synthesis is typically catalyzed by lipoxygenases, enzymes that convert polyunsaturated fatty acids into biologically active metabolites. The compound's stereochemistry, particularly the (R) configuration, is crucial for its interaction with specific receptors and enzymes, impacting its overall efficacy and function in biological systems. Research into 11(R)-HETE continues to explore its potential therapeutic applications, particularly in the context of cardiovascular health and inflammatory diseases.

Formula: C₂₀H₃₂O₃

InChI: InChI=1S/C20H32O3/c1-2-3-4-5-7-10-13-16-19(21)17-14-11-8-6-9-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b9-6-,10-7-,14-11-,16-13+/t19-/m0/s1

InChI key: InChIKey=GCZRCCHPLVMMJE-WXMXURGXSA-N

SMILES: [C@@H](C/C=C\C/C=C\CCCC(O)=O)(/C=C/C=C\CCCCC)O

Synonyms:

• (5E,8Z,11R,12Z,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoic acid
• (5Z,8Z,11R,12E,14Z)-11-Hydroxy-5,8,12,14-eicosatetraenoic acid
• (5Z,8Z,11R,12E,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoic acid
• 11(R)-Hete
• 5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, (5Z,8Z,11R,12E,14Z)-
• 5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, [R-(E,Z,Z,Z)]-
• [11R-(5Z,8Z,12E,14Z)]-11-Hydroxy-5,8,12,14-eicosatetraenoic acid

11(R)-HETE

CAS: 73347-43-0

11(R)-HETE aids in oocyte maturation in sea urchins and tentacle regeneration in hydras; it is also made by aspirin-influenced COX-2 and arachidonic acid.

Formula: C₂₀H₃₂O₃

Color and Shape: Solid

Molecular weight: 320.473

Ref: TM-T37490

11(R)-hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid

CAS: 73347-43-0

Formula: C20H32O3

Purity: >98%

Color and Shape: In solution, Ethanol

Molecular weight: 320.47

Ref: 48-14-6042

11(R)-Hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid

CAS: 73347-43-0

11(R)-Hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid is a bioactive lipid compound, which is a metabolite of arachidonic acid derived primarily from the enzymatic activity of lipoxygenases and epoxygenases. It plays a significant role in the pathway yielding eicosanoids, a group of signaling molecules involved in various physiological and pathological processes.

Formula: C₂₀H₃₂O₃

Purity: Min. 95%

Molecular weight: 320.5 g/mol

Ref: 3D-YCA34743