CAS 7336-33-6
:3-Demethylcolchicine
Description:
3-Demethylcolchicine is a chemical compound derived from colchicine, a well-known alkaloid primarily extracted from the plant Colchicum autumnale. This compound is characterized by its structural modifications that result in the removal of a methyl group from the colchicine molecule. It exhibits properties typical of alkaloids, including a complex ring structure and the presence of multiple functional groups that contribute to its biological activity. 3-Demethylcolchicine is recognized for its potential use in research, particularly in studies related to cell division and cancer treatment, as it can inhibit microtubule formation, thereby affecting mitosis. The compound is typically a white to off-white solid and is soluble in organic solvents. Its pharmacological profile is of interest in medicinal chemistry, although it may also exhibit toxicity, necessitating careful handling and usage in laboratory settings. As with many alkaloids, the specific interactions and effects of 3-Demethylcolchicine are subjects of ongoing research, particularly in the context of its therapeutic applications.
Formula:C21H23NO6
InChI:InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-17(25)20(27-3)21(28-4)19(12)13-6-8-18(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
InChI key:InChIKey=JRRUSQGIRBEMRN-HNNXBMFYSA-N
SMILES:O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC(O)=C1OC)=CC(=O)C(OC)=CC3
Synonyms:- Acetamide, N-(5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
- Colchicine, O3-demethyl-
- Benzo[a]heptalene, acetamide deriv.
- Colchicine, 2-demethyl-
- Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
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Found 11 products.
N-[(7S,12aRa)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide (3-O-Demethylcolchicine)
CAS:Controlled ProductFormula:C21H23NO6Color and Shape:NeatMolecular weight:385.413-demethylcolchicine
CAS:3-demethylcolchicine is a natural product isolated from Gloriosa superba.Inhibitory effect on the polymerization of purified bovine brain tubulin.Formula:C21H23NO6Purity:98.24% - 99.03%Color and Shape:SolidMolecular weight:385.41Ref: TM-TN6706
1mgTo inquire5mg225.00€10mg359.00€25mg557.00€50mg820.00€100mg1,121.00€1mL*10mM (DMSO)269.00€3-Demethyl Colchicine
CAS:<p>Applications A metabolite of Colchicine (C640000). Has shown anti-tumor activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinez, M., et al.: J. Appl. Toxicol., 15, 49 (1995), De Vincenzo, R., et al.: Oncol. Res., 11, 145(1999), Das, D., et al.: Biochim. Biophys. Acta., 1502, 351 (2000), Wagner, B., et al.: J. Biol. Chem., 275, 22461(2000),<br></p>Formula:C21H23NO6Color and Shape:NeatMolecular weight:385.41(-)-3-Demethylcolchicine
CAS:<p>(-)-3-Demethylcolchicine is a natural compound, which is an analog of demecolcine. It has been shown to be toxic to cancer cells in vitro and has been used in the treatment of colon cancer. (-)-3-Demethylcolchicine appears to inhibit the activity of gamma-aminobutyric acid (GABA) receptors and inhibits the proliferation of hl-60 cells in culture. (-)-3-Demethylcolchicine also has hemolytic activity, which may be due to its ability to bind to red blood cells.</p>Formula:C21H23NO6Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:385.41 g/mol
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