CAS 73384-59-5

Ceftriaxone

Description:

Ceftriaxone is a broad-spectrum cephalosporin antibiotic used primarily to treat a variety of bacterial infections. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against both Gram-positive and Gram-negative bacteria. Ceftriaxone is typically administered via intramuscular or intravenous routes due to its poor oral bioavailability. It has a long half-life, allowing for once-daily dosing in many cases. The substance is soluble in water, which facilitates its use in clinical settings. Ceftriaxone is known for its stability against certain beta-lactamases, enzymes produced by some bacteria that confer resistance to other antibiotics. However, it is not effective against all bacterial strains, and resistance can develop. Common side effects may include allergic reactions, gastrointestinal disturbances, and alterations in liver function tests. Due to its broad activity, ceftriaxone is often used in treating severe infections, including pneumonia, meningitis, and sepsis, and is a critical component of empirical therapy in many clinical guidelines.

Formula: C₁₈H₁₈N₈O₇S₃

InChI: InChI=1/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-

InChI key: InChIKey=VAAUVRVFOQPIGI-SPQHTLEESA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1CSC=4N(C)NC(=O)C(=O)N4)[H]

Synonyms:

• (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-Thiazol-4-Yl)-2-Methoxyiminoacetyl]Amino]-3-[(2-Methyl-5,6-Dioxo-1H-1,2,4-Triazin-3-Yl)Sulfanylmethyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, (6R,7R)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-
• 7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Biotrakson
• Ceftriaxon
• Ceftriaxona
• Epicephin
• Rocefin
• Rocephalin
• Rophex
• Ceftriaxone
• (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Antibiotic Ro-13-9904
• CEFTRIAZONE
• CEFATRIAXONE
• Rocephin(e)

Ceftriaxone Disodium Salt Hemiheptahydrate

CAS: 104376-79-6, 73384-59-5, 74578-69-1

Formula: C₁₈H₁₆N₈Na₂O₇S₃H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 661.58

Ref: 3B-C2226

Ceftriaxone

CAS: 73384-59-5

Formula: C₁₈H₁₈N₈O₇S₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 554.5799

Ref: IN-DA019FVC

Ceftriaxone

CAS: 73384-59-5

Ceftriaxone

Purity: ≥95%

Molecular weight: 554.58g/mol

Ref: 54-BUP00460

Ceftriaxone

CAS: 73384-59-5

Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.

Formula: C₁₈H₁₈N₈O₇S₃

Purity: 96.08%

Color and Shape: Solid

Molecular weight: 554.58

Ref: TM-T75295

Ceftriaxone Disodium Salt

CAS: 104376-79-6, 73384-59-5

Formula: C₁₈H₁₆N₈O₇S₃·2Na

Molecular weight: 552.57 2*22.99

Ref: 4Z-C-939

Ceftriaxone

CAS: 73384-59-5

Applications Ceftriaxone is an antibacterial, a third-generation cephalosporin.
References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)

Formula: C₁₈H₁₈N₈O₇S₃

Color and Shape: Off-White To Light Yellow

Molecular weight: 554.58

Ref: TR-C244995