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CAS 735-52-4

:

Cetophenicol

Description:
Chloramphenicol, with the CAS number 735-52-4, is a broad-spectrum antibiotic originally derived from the bacterium Streptomyces venezuelae. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, making it effective against a variety of Gram-positive and Gram-negative bacteria. Chloramphenicol is a colorless, crystalline solid that is soluble in water and organic solvents, which facilitates its use in various formulations, including oral, intravenous, and topical applications. While it is effective in treating serious infections, its use is limited due to potential side effects, such as aplastic anemia and gray baby syndrome in newborns. Chloramphenicol is also known for its ability to penetrate well into tissues and the central nervous system, making it useful for treating infections like meningitis. However, due to the risk of serious adverse effects, its use is often reserved for specific situations where other antibiotics are ineffective or contraindicated.
Formula:C13H15Cl2NO4
InChI:InChI=1S/C13H15Cl2NO4/c1-7(18)8-2-4-9(5-3-8)11(19)10(6-17)16-13(20)12(14)15/h2-5,10-12,17,19H,6H2,1H3,(H,16,20)/t10-,11-/m1/s1
InChI key:InChIKey=PKUBDVAOXLEWBF-GHMZBOCLSA-N
SMILES:[C@@H]([C@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(C(C)=O)C=C1
Synonyms:
  • Acetamide, N-[(1R,2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-
  • Acetamide, N-[2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-, [R-(R*,R*)]-
  • Acetamide, N-[p-acetyl-β-hydroxy-α-(hydroxymethyl)phenethyl]-2,2-dichloro-, D-threo-
  • N-[(1R,2R)-2-(4-Acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloroacetamide
  • W 3746
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