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CAS 73547-61-2

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Ceftazidime sodium

Description:
Ceftazidime sodium is a broad-spectrum cephalosporin antibiotic used primarily to treat infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. It is a semi-synthetic derivative of cephalosporin and is characterized by its beta-lactam structure, which is essential for its antibacterial activity. Ceftazidime sodium is typically administered via injection and is soluble in water, making it suitable for intravenous or intramuscular use. The compound exhibits stability against certain beta-lactamases, enzymes produced by bacteria that can inactivate many antibiotics. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Ceftazidime is often used in hospital settings for serious infections, including pneumonia, urinary tract infections, and sepsis. Common side effects may include gastrointestinal disturbances, allergic reactions, and potential impacts on renal function. As with all antibiotics, it is crucial to use ceftazidime judiciously to minimize the development of antibiotic resistance.
Formula:C22H23N6NaO7S2
InChI:InChI=1/C22H22N6O7S2.Na/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);/q;+1/p-1/b26-13+;/t14-,18-;/m1./s1
InChI key:InChIKey=TYXUEFZGOSECKS-ROMZVAKDSA-N
SMILES:C([O-])(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC(C(O)=O)(C)C)/C3=CSC(N)=N3)=O)C2=O)(SCC1C[N+]=4C=CC=CC4)[H].[Na]
Synonyms:
  • Ceftazidime sodium in plastic container
  • 2H6]-Ceftazidime sodium salt
  • GR 20263 monosodium salt
  • Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, monosodium salt
  • Ceftazidime sodium salt
  • Ceftazidime sodium USP/EP/BP
  • Pyridinium, 1-[[7-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, monosodium salt, [6R-[6α,7β(Z)]]-
  • Ceftazidime sodium sodium salt
  • UNII-CMC30V039K
  • GR 20263 monosodium salt
  • See more synonyms
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