CAS 73573-88-3
:Mevastatin
Description:
Mevastatin, also known as compactin, is a naturally occurring statin that is primarily used for its cholesterol-lowering properties. It is derived from the fermentation of certain fungi, particularly Penicillium citrinum. The chemical structure of mevastatin features a lactone ring and a hydroxy acid moiety, which are crucial for its biological activity. As an inhibitor of HMG-CoA reductase, mevastatin plays a significant role in the mevalonate pathway, effectively reducing the synthesis of cholesterol in the liver. This action helps lower low-density lipoprotein (LDL) cholesterol levels in the bloodstream, thereby reducing the risk of cardiovascular diseases. Mevastatin is typically administered in its active form, which is the hydroxy acid, as the lactone form is converted to the active form in the body. While it has been used in research and has historical significance in the development of statin drugs, its clinical use has largely been supplanted by more potent and widely studied statins. As with all medications, potential side effects and interactions should be considered when evaluating its use.
Formula:C23H34O5
InChI:InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChI key:InChIKey=AJLFOPYRIVGYMJ-INTXDZFKSA-N
SMILES:C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@]3([C@@H](OC([C@H](CC)C)=O)CCC=C3C=C[C@@H]2C)[H]
Synonyms:- (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
- 2-Methyl-butanoic acid [1S-[1-alpha(R*),7-beta,8-beta(2S*,4S*),8a-beta]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester
- Antibiotic ML 236B
- Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
- Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),7β,8β(2S*,4S*),8aβ]]-
- CS 500 (antibiotic)
- Compactin (Penicillium)
- Cs 500
- L 637312
- ML 236B lactone
- Mevastatin
- Ml-236B
- NSC 281245
- Statin I
- See more synonyms
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Found 16 products.
Mevastatin
CAS:Formula:C23H34O5Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:390.52Mevastatin, 98%
CAS:<p>Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close str</p>Formula:C23H34O5Purity:98%Color and Shape:Powder or crystals or crystalline powderMolecular weight:390.52Mevastatin ((1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate)
CAS:<p>Lactones, nesoi</p>Formula:C23H34O5Color and Shape:Yellow Pale Yellow PowderMolecular weight:390.24062Mevastatin
CAS:<p>Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.</p>Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
CAS:Formula:C23H34O5Purity:95%Color and Shape:SolidMolecular weight:390.5131Mevastatin
CAS:Formula:C23H34O5Purity:≤ 0.5%Color and Shape:White to light-yellow crystalline powderMolecular weight:390.52Mevastatin (Compactin)
CAS:Formula:C23H34O5Color and Shape:White To Off-White SolidMolecular weight:390.52Mevastatin
CAS:Controlled Product<p>Applications A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.<br>References Endo, A., et al.: FEBS Letters, 72, 323 (1976), Endo, A.: J. Med. Chem., 28, 401 (1985)<br></p>Formula:C23H34O5Color and Shape:White To Off-WhiteMolecular weight:390.51Mevastatin - Bio-X ™
CAS:<p>Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.</p>Formula:C23H34O5Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:390.51 g/molMevastatin
CAS:<p>Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity. In addition, it has been shown to induce neuronal death in a polymerase chain reaction assay by inhibiting DNA synthesis.</p>Formula:C23H34O5Purity:Min. 95%Color and Shape:PowderMolecular weight:390.51 g/molMevastatin
CAS:<p>M02108 - Mevastatin</p>Formula:C23H34O5Purity:95%Color and Shape:SolidMolecular weight:390.52
