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CAS 73604-30-5

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(-)-bicuculline methobromide

Description:
(-)-Bicuculline methobromide is a chemical compound that serves primarily as a competitive antagonist of the GABA (gamma-aminobutyric acid) receptor, particularly the GABA_A subtype. This compound is derived from the plant species *Bicuculla*, which is known for its alkaloid content. It is characterized by its ability to inhibit the effects of GABA, a major inhibitory neurotransmitter in the central nervous system, thereby influencing neuronal excitability and synaptic transmission. The methobromide form indicates that it is a quaternary ammonium salt, which enhances its solubility and stability in biological systems. (-)-Bicuculline methobromide is often utilized in neuropharmacological research to study the role of GABAergic signaling in various physiological and pathological processes. Its effects can lead to increased neuronal excitability, making it a valuable tool for investigating seizure activity and other neurological conditions. As with many pharmacological agents, careful handling and consideration of its effects are essential in experimental settings.
Formula:C21H20BrNO6
InChI:InChI=1/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)17-12-3-4-14-20(27-10-24-14)19(12)28-21(17)23;/h3-4,7-8,17-18H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t17-,18+;/m1./s1
Synonyms:
  • (6R)-6-[(5R)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,2-g][1,3]benzodioxol-7-one bromide
  • (-)-BICUCULLINE 1(S),9(R) METHBROMIDE
  • (-)-BICUCULLINE METHOBROMIDE
  • (R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq
  • [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
  • [R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM BROMIDE
  • (-）Bicucullinemethobromide
  • Bicuculinemethoiodide
  • [R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINDINIUM BROMIDE
  • Bicuculineracemic
  • l-Bicuculline methobromide
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