CAS 73681-12-6

Indecainide Hydrochloride

Description:

Indecainide hydrochloride is a pharmaceutical compound primarily used as an antiarrhythmic agent. It belongs to the class of drugs known as sodium channel blockers, which function by inhibiting the influx of sodium ions during the depolarization phase of cardiac action potentials. This action helps to stabilize the cardiac membrane and restore normal rhythm in patients experiencing arrhythmias. The compound is typically administered in its hydrochloride salt form, which enhances its solubility and bioavailability. Indecainide hydrochloride is characterized by its specific molecular structure, which includes a piperidine ring and an aromatic moiety, contributing to its pharmacological properties. It is important to note that, like many medications, it may have side effects and contraindications, necessitating careful monitoring and dosage adjustments in clinical settings. The compound is not widely used today, as newer antiarrhythmic agents have emerged, but it remains a point of interest in pharmacological studies and historical contexts of cardiac treatment.

Formula: C₂₀H₂₄N₂OClH

InChI: InChI=1/C20H24N2O.ClH/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-9-4-6-11-18(16)20;/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23);1H

SMILES: CC(C)NCCCC1(c2ccccc2c2ccccc12)C(=N)O.Cl

Synonyms:

• Indecainide hydrochloride [USAN]
• 9-(3-((1-Methylethyl)amino)propyl)-9H-fluorene-9-carboxamide hydrochloride
• 9-(3-(Isopropylamino)propyl)fluorene-9-carboxamide monohydrochloride
• 9H-Fluorene-9-carboxamide, 9-(3-((1-methylethyl)amino)propyl)-, monohydrochloride
• Decabid
• Indecainide HCl
• Ly 135837
• Unii-M76V0B96L5
• Indecainide hydrochloride

Indecainide hydrochloride

CAS: 73681-12-6

Indecainide hydrochloride is a cardiac depressant.

Formula: C₂₀H₂₅ClN₂O

Color and Shape: Solid

Molecular weight: 344.88

Ref: TM-T32155L

Indecainide Hydrochloride

Controlled Product

CAS: 73681-12-6

Formula: C₂₀H₂₄N₂O·ClH

Color and Shape: Neat

Molecular weight: 344.878

Ref: TR-I510000

Indecainide hydrochloride

CAS: 73681-12-6

Indecainide hydrochloride is a potent inhibitor of ion channels that are gated by voltage, such as sodium and calcium. It is an activator of the beta-adrenergic receptor. Indecainide hydrochloride binds to the beta-adrenergic receptor in the cytoplasm and stabilizes the receptor in its active state, thereby increasing its affinity for acetylcholine and norepinephrine. This drug has been shown to inhibit ligand-gated ion channels, such as nicotinic acetylcholine receptors and serotonin 5HT2A receptors. It also inhibits peptides that bind to receptors, such as substance P (SP) and calcitonin gene-related peptide (CGRP).

Formula: C₂₀H₂₅ClN₂O

Purity: Min. 95%

Molecular weight: 344.90 g/mol

Ref: 3D-YCA68112