CAS 73736-50-2

Desmethylastemizole

Description:

Desmethylastemizole, with the CAS number 73736-50-2, is a chemical compound that is a derivative of astemizole, an antihistamine that was previously used for allergic conditions. This substance is characterized by its structural modifications, specifically the absence of a methyl group, which influences its pharmacological properties. Desmethylastemizole exhibits antihistaminic activity, although it is less potent than its parent compound. It is known to interact with histamine H1 receptors, which play a crucial role in allergic responses. Additionally, desmethylastemizole has been studied for its potential effects on cardiac ion channels, particularly its ability to prolong the QT interval, which can lead to serious cardiac arrhythmias. The compound is typically analyzed using techniques such as chromatography and mass spectrometry for purity and identification. Due to safety concerns associated with its parent compound, the clinical use of desmethylastemizole is limited, and it is primarily of interest in research settings.

Formula: C₂₇H₂₉FN₄O

InChI: InChI=1S/C27H29FN4O/c28-22-9-5-21(6-10-22)19-32-26-4-2-1-3-25(26)30-27(32)29-23-14-17-31(18-15-23)16-13-20-7-11-24(33)12-8-20/h1-12,23,33H,13-19H2,(H,29,30)

InChI key: InChIKey=LAGYWHSFHIMTPE-UHFFFAOYSA-N

SMILES: C(N1C(NC2CCN(CCC3=CC=C(O)C=C3)CC2)=NC=4C1=CC=CC4)C5=CC=C(F)C=C5

Synonyms:

• 4-[2-[4-[[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]phenol
• Desmethylastemizole
• O-Demethylastemizole
• R 44271
• phenol, 4-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-

O-Desmethyl Astemizole

CAS: 73736-50-2

Formula: C₂₇H₂₉FN₄O

Color and Shape: White To Off-White Solid

Molecular weight: 444.55

Ref: 4Z-A-157001

O-Desmethyl Astemizole-d4

CAS: 73736-50-2

Formula: C₂₇H₂₅D₄FN₄O

Color and Shape: White To Off-White Solid

Molecular weight: 448.58

Ref: 4Z-A-157002

O-Desmethyl Astemizole

Controlled Product

CAS: 73736-50-2

Applications A metabolite of Astemizole.
References Nagata, K., et al.: J. Biol. Chem., 268, 24720 (1993), Benton, R., et al.: Clin. Pharmacol. Ther., 59, 383 (1996), Hashizume, T., et al.: Drug Metab. Dispos., 26, 566 (1998), Scarborough, P., et al.: Drug Metab. Rev., 31, 205 (1999),

Formula: C₂₇H₂₉FN₄O·ClH

Color and Shape: Neat

Molecular weight: 481.00

Ref: TR-D290750

4-(2-(4-((1-((4-Fluorophenyl)methyl)-1H-benzimidazol-2-yl)amino)-1-piperidinyl)ethyl)-phenol

CAS: 73736-50-2

4-(2-(4-((1-((4-Fluorophenyl)methyl)-1H-benzimidazol-2-yl)amino)-1-piperidinyl)ethyl)-phenol is a drug used to treat allergic symptoms and structural heart disease. It is an analog of erythromycin that has been shown to inhibit multidrug efflux pumps, which are proteins that pump drugs out of the bacterial cell. 4-(2-(4-((1-((4-Fluorophenyl)methyl)-1H-benzimidazol-2-yl)amino)-1-piperidinyl)ethyl)-phenol binds to the receptor site on the outside of cells, preventing its activation by histamine or other chemical substances. This binding leads to an increase in histamine levels and a decrease in inflammation.

Formula: C₂₇H₂₉FN₄O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 444.54 g/mol

Ref: 3D-FF101863

O-Desmethyl Astemizole-d5

Controlled Product

CAS: 73736-50-2

Formula: C₂₇D₅H₂₄FN₄O

Color and Shape: Neat

Molecular weight: 449.575

Ref: TR-D290752

O-Desmethyl Astemizole

CAS: 73736-50-2

Formula: C₂₇H₂₉FN₄O

Molecular weight: 444.55

Ref: ST-EA-CP-A215001