CAS 73781-91-6

Methyl 6-chloronicotinate

Description:

Methyl 6-chloronicotinate is an organic compound that belongs to the class of nicotinic acid derivatives. It features a pyridine ring substituted with a chlorine atom at the 6-position and a methoxycarbonyl group (methyl ester) at the 3-position. This compound is typically a colorless to pale yellow liquid or solid, depending on its purity and form. Methyl 6-chloronicotinate is known for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals due to its structural similarity to biologically active compounds. It exhibits moderate solubility in organic solvents and limited solubility in water, which is characteristic of many aromatic compounds. The presence of the chlorine atom can influence its reactivity and biological activity, making it a subject of interest in various chemical syntheses and studies. As with many chemical substances, proper handling and safety precautions are essential, as it may pose health risks if ingested or inhaled.

Formula: C₇H₆ClNO₂

InChI: InChI=1/C7H6ClNO2/c1-11-7(10)5-2-3-6(8)9-4-5/h2-4H,1H3

SMILES: COC(=O)c1ccc(Cl)nc1

Synonyms:

• 6-Chloronicotinic acid methyl ester
• Methyl 6-chloropyridine-3-carboxylate
• 3-Pyridinecarboxylic acid, 6-chloro-, methyl ester

Methyl 6-Chloronicotinate

CAS: 73781-91-6

Formula: C₇H₆ClNO₂

Purity: >98.0%(GC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 171.58

Ref: 3B-M1980

Methyl 6-chloronicotinate, 98%

CAS: 73781-91-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₆ClNO₂

Purity: 98%

Color and Shape: Pale cream to cream to pale brown, Crystals or powder or crystalline powder

Molecular weight: 171.58

Ref: 02-A10396

Methyl 6-chloronicotinate

CAS: 73781-91-6

Formula: C₇H₆ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 171.5810

Ref: IN-DA003RYF

Methyl 6-chloronicotinate

CAS: 73781-91-6

Methyl 6-chloronicotinate

Formula: C₇H₆ClNO₂

Purity: 98%

Color and Shape: light yellow flakes

Molecular weight: 171.58g/mol

Ref: 54-OR27398

Methyl 6-chloronicotinate

CAS: 73781-91-6

Formula: C₇H₆ClNO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 171.58

Ref: 10-F306989

Methyl 6-Chloronicotinate

Controlled Product

CAS: 73781-91-6

Applications Methyl 6-Chloronicotinate is used in the determination of Acetamiprid (A150800) and its metabolites in crop and soil.
References Tokieda, M., et al.: Nippon Noyaku Gakkaishi, 24, 115 (1999)

Formula: C₇H₆ClNO₂

Color and Shape: Neat

Molecular weight: 171.58

Ref: TR-M295275

Methyl 6-chloronicotinate

CAS: 73781-91-6

Methyl 6-chloronicotinate is a quinoline derivative that has been shown to have cytotoxic effects. This compound inhibits the DNA repair protein O6-alkylguanine-DNA alkyltransferase (O6-AGAT) and induces apoptosis by binding to the cation channel and inhibiting the influx of calcium ions, which leads to an increase in intracellular calcium levels. Methyl 6-chloronicotinate also inhibits cancer cell proliferation through its interaction with the voltage-gated sodium channels and potassium channels, which leads to cell death. The molecular modeling study revealed that methyl 6-chloronicotinate binds to a deep hydrophobic pocket on the surface of hct116 cells, indicating that this drug may be a potential anticancer agent.

Formula: C₇H₆ClNO₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 171.58 g/mol

Ref: 3D-FM36752