CAS 738-70-5

Trimethoprim

Description:

Trimethoprim is an antibiotic primarily used to treat bacterial infections, particularly urinary tract infections. It functions as a dihydrofolate reductase inhibitor, disrupting the bacterial synthesis of folate, which is essential for DNA and RNA production. The chemical formula of trimethoprim is C14H18N4O3, and it has a molecular weight of approximately 290.33 g/mol. This compound is typically a white to off-white crystalline powder that is soluble in water and methanol but has limited solubility in organic solvents like chloroform. Trimethoprim exhibits a moderate to high bioavailability when administered orally and is often combined with sulfamethoxazole to enhance its antibacterial efficacy, as seen in the co-trimoxazole formulation. Its pharmacokinetics include rapid absorption and distribution, with a half-life that allows for once or twice daily dosing. Trimethoprim is generally well-tolerated, though it can cause side effects such as gastrointestinal disturbances and, in rare cases, hematological reactions.

Formula: C₁₄H₁₈N₄O₃

InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key: InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N

SMILES: C(C1=CC(OC)=C(OC)C(OC)=C1)C=2C(N)=NC(N)=NC2

Synonyms:

• 2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine
• 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
• 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-
• 5-((3,4,5-Trimethoxyphenyl)Methyl)-2,4-Pyrimidinediamine
• 5-(3,4,5-Trimethoxybenzyl)Pyrimidine-2,4-Diyldiamine
• Antibiotic synergist
• Bw 56-72
• Infectotrimet
• Instalac
• Monotrim
• Nih 204
• Nsc 106568
• Proloprim
• Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-
• Syraprim
• Tiempe
• Trimanyl
• Trimethioprim
• Trimethoprim Crystalline
• Trimethoprim(TMP)
• Trimethoprime
• Trimetoprim
• Trimetoprima
• Trimogal
• Trimopan
• Trimpex
• Triprim
• Uretrim

Trimethoprim 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 738-70-5

Formula: C₁₄H₁₈N₄O₃

Color and Shape: Single Solution

Molecular weight: 290.32

Ref: 04-A17875000AL-1000

Sulfonamides Mixture for GB/T 21316-2007 100 µg/mL in Acetonitrile

Controlled Product

CAS: 122-11-2, 122-16-7, 1220-83-3, 127-69-5, 127-71-9, 127-79-7, 144-80-9, 144-82-1, 144-83-2, 2447-57-6, 515-64-0, 526-08-9, 57-67-0, 57-68-1, 59-40-5, 651-06-9, 68-35-9, 72-14-0, 723-46-6, 729-99-7, 738-70-5, 80-32-0, 80-35-3

Color and Shape: Mixture

Ref: 04-GA09000590AL

Trimethoprim

CAS: 738-70-5

Applications Antibacterial. This compound is a contaminant of emerging concern (CECs).
References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),

Formula: C₁₄H₁₈N₄O₃

Color and Shape: Off-White

Molecular weight: 290.32

Ref: TR-T795615

Trimethoprim

CAS: 738-70-5

Trimethoprim is a diaminopyrimidine antibiotic with action on bacterial folate synthesis inhibition and is used for treating urinary tract infections and respiratory infections.

Formula: C₁₄H₁₈N₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 290.32 g/mol

Ref: 3D-AT28516

Trimethoprim (TMP), 98.5%

CAS: 738-70-5

Formula: C₁₄H₁₈N₄O₃

Purity: min. 98.5%

Color and Shape: White to Off-white, Crystalline powder

Molecular weight: 290.32

Ref: SR-18879

Trimethoprim-15N3

Controlled Product

CAS: 738-70-5

Formula: C₁₄H₁₈₁₅N₃NO₃

Color and Shape: Neat

Molecular weight: 293.298

Ref: TR-T795619

α-Hydroxy Trimethoprim Glucuronide

Controlled Product

CAS: 738-70-5

Formula: C₂₀H₂₆N₄O₁₀

Color and Shape: Neat

Molecular weight: 482.441

Ref: TR-H971870