CAS 7380-40-7
:Bergamottin
Description:
Bergamottin is a naturally occurring compound classified as a furanocoumarin, primarily found in the essential oil of bergamot oranges (Citrus bergamia). It is known for its role in the grapefruit juice effect, where it can inhibit certain cytochrome P450 enzymes, particularly CYP3A4, which affects the metabolism of various drugs. This inhibition can lead to increased bioavailability of certain medications, potentially resulting in adverse effects or altered therapeutic outcomes. Bergamottin is a colorless to pale yellow liquid with a characteristic citrus aroma, and it is soluble in organic solvents but has limited solubility in water. In addition to its pharmacological implications, bergamottin is also studied for its potential health benefits, including antioxidant and anti-inflammatory properties. However, due to its effects on drug metabolism, caution is advised when consuming bergamot products alongside certain medications. Overall, bergamottin exemplifies the complex interactions between natural compounds and pharmaceutical agents, highlighting the importance of understanding dietary influences on drug efficacy.
Formula:C21H22O4
InChI:InChI=1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+
InChI key:InChIKey=DBMJZOMNXBSRED-OQLLNIDSSA-N
SMILES:O(C/C=C(/CCC=C(C)C)\C)C=1C2=C(C=C3C1C=CO3)OC(=O)C=C2
Synonyms:- 4-[[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one
- 4-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one
- 5-Geranoxypsoralen
- 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3,7-dimethyl-2,6-octadienyl)oxy]-, (E)-
- 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-
- 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-3,7-dimethyl-2,6-octadienyl]oxy]-
- Bergamotine
- Bergaptin
- Bergamottin
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Found 9 products.
Bergamottin
CAS:Bergamottin analytical standard provided with w/w absolute assay, to be used for quantitative titration.Formula:C21H22O4Purity:(HPLC) ≥99%Color and Shape:PowderMolecular weight:338.41Bergamottin
CAS:Formula:C21H22O4Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:338.40Bergamottin
CAS:<p>1.</p>Formula:C21H22O4Purity:97.59% - 99.99%Color and Shape:SolidMolecular weight:338.4Bergamottin
CAS:LactoneFormula:C21H22O4Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:338.4Bergamottin
CAS:<p>Applications Bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction.<br>References Bailey, D., et al.: Clin. Pharmacol. Ther., 68, 468 (2000), Guo, L., et al.; Drug Metab. Dispos., 28, 766 (2000), Baer, B., et al.: Chem. Res. Toxicol., 20, 954 (2007), Lin, H., et al.: Drug Metab. Dispos., 39, 24 (2011);<br></p>Formula:C21H22O4Color and Shape:NeatMolecular weight:338.40Bergamottin
CAS:<p>Bergamottin is a furanocoumarin compound, which is primarily found in grapefruit juice and other citrus fruits. It is derived from natural sources, specifically within the fruit and peel of grapefruits. The mode of action of Bergamottin involves the inhibition of the cytochrome P450 enzymes, particularly CYP3A4, which play a significant role in the metabolism of various drugs. This inhibitory effect can alter the pharmacokinetics of certain medications by increasing their bioavailability.</p>Formula:C21H22O4Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:338.4 g/mol
