CAS 73803-48-2

Tripamide

Description:

Tripamide is a chemical compound classified as a diuretic, primarily used in the treatment of hypertension and edema. It belongs to the class of thiazide-like diuretics, which function by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased urine output and decreased blood volume. This mechanism helps lower blood pressure and reduce fluid retention. Tripamide is characterized by its ability to promote diuresis while maintaining electrolyte balance, although it may still lead to potential side effects such as electrolyte imbalances, dehydration, or hypotension. The compound is typically administered orally and is often prescribed in conjunction with other antihypertensive agents to enhance therapeutic efficacy. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are essential for understanding its clinical applications and potential interactions with other medications. As with any medication, it is crucial for patients to follow their healthcare provider's guidance regarding dosage and monitoring for adverse effects.

Formula: C₁₆H₂₀ClN₃O₃S

InChI: InChI=1/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12-,13+

InChI key: InChIKey=UHLOVGKIEARANS-NIFPGPBJNA-N

SMILES: N(C(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1)N2C[C@]3([C@]([C@@]4(C[C@]3(CC4)[H])[H])(C2)[H])[H]

Synonyms:

• 4,7-Methano-2H-isoindole, benzamide deriv.
• 4-Chlor-N-(endo-perhydro-4,7-methano-2-isoindolyl)-3-sulfamoylbenzamid
• 4-Chloro-N-(endo-hexahydro-4,7-methanoisoindolin-2-yl)-3-sulfamoylbenzamide
• 4-chloro-N-[(3aR,4S,7R,7aS)-octahydro-2H-4,7-methanoisoindol-2-yl]-3-sulfamoylbenzamide
• 4-chloro-N-[(3aR,7R,7aS)-octahydro-2H-4,7-methanoisoindol-2-yl]-3-sulfamoylbenzamide
• Adr 033
• Benzamide, 3-(aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)-, (3aalpha,4alpha,7alpha,7aalpha)-
• Benzamide, 3-(aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)-, (3aα,4α,7α,7aα)-
• Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(3aR,4R,7S,7aS)-octahydro-4,7-methano-2H-isoindol-2-yl]-, rel-
• Brn 1663663
• E 614
• N-(4-Aza-endo-tricyclo(5.2.1.5(sup 2,6))-decan-4-yl)-4-chloro-3-sulfamoylbenzamide
• Normonal
• TDS (diuretic)
• Toripamide
• Tripamida
• Tripamida [INN-Spanish]
• Tripamide [USAN:INN:JAN]
• Tripamidum
• Tripamidum [INN-Latin]
• Unii-G36A0E9Cvt
• endo-4-Chloro-N-(hexahydro-4,7-methanoisoindol-2-yl)-3-sulfamoylbenzamide
• rel-3-(Aminosulfonyl)-4-chloro-N-[(3aR,4R,7S,7aS)-octahydro-4,7-methano-2H-isoindol-2-yl]benzamide
• Tripamide
• Tripamide
• 5-20-05-00123 (Beilstein Handbook Reference)
• Normonal (tn)
• 3-(Aminosulfonyl)-4-chloro-N-[(3aβ,7aβ)-4β,7β-methanooctahydro-2H-isoindol-2-yl]benzamide
• Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(3aR,4R,7S,7aS)-octahydro-4,7-methano-2H-isoindol-2-yl]-, rel- (9CI)
• D01895
• 4-Chloro-N-(1,3,3aβ,4,5,6,7,7aβ-octahydro-4β,7β-methano-2H-isoindol-2-yl)-3-sulfamoylbenzamide
• UHLOVGKIEARANS-NIFPGPBJSA-N

Tripamide

CAS: 73803-48-2

Formula: C₁₆H₂₀ClN₃O₃S

Color and Shape: Solid

Molecular weight: 369.8663

Ref: IN-DA00FWJB

Tripamide

Controlled Product

CAS: 73803-48-2

Applications Tripamide is a diuretic.
References Ogihara, T., et al.: Hypert. Res., 32, 163 (2009)

Formula: C₁₆H₂₀ClN₃O₃S

Color and Shape: Neat

Molecular weight: 369.87

Ref: TR-T805560

Tripamide-d4

Controlled Product

CAS: 73803-48-2

Formula: C₁₆D₄H₁₆ClN₃O₃S

Color and Shape: Neat

Molecular weight: 373.891

Ref: TR-T805562