CAS 7413-34-5

Sodium methotrexate

Description:

Sodium methotrexate is the sodium salt form of methotrexate, a potent antimetabolite and antifolate medication primarily used in the treatment of certain cancers and autoimmune diseases. It functions by inhibiting the enzyme dihydrofolate reductase, which is crucial for DNA synthesis and cell replication. This compound appears as a white to yellowish crystalline powder and is soluble in water, making it suitable for intravenous or intramuscular administration. Sodium methotrexate has a relatively high molecular weight and is characterized by its ability to interfere with folate metabolism, leading to the inhibition of cell growth, particularly in rapidly dividing cells. It is important to note that the use of sodium methotrexate requires careful monitoring due to potential side effects, including toxicity to normal cells, particularly in the gastrointestinal tract and bone marrow. Additionally, it has a well-defined pharmacokinetic profile, with its absorption, distribution, metabolism, and excretion influenced by various factors, including dosage and patient-specific characteristics.

Formula: C₂₀H₂₂N₈O₅·2Na

InChI: InChI=1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/t13-;;/m0../s1

InChI key: InChIKey=HQRCOVOSZPGUCA-GXKRWWSZSA-N

SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1.[Na]

Synonyms:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodium salt
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2)
• Amethopterin sodium
• Disodium 2-[(4-{[(2,4-Diaminopteridin-6-Yl)Methyl](Methyl)Amino}Benzoyl)Amino]Pentanedioate
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodium salt, <span class="text-smallcaps">L</span>-(+)-
• Methotrexate Lederle
• Methotrexate disodium
• Metoart
• Metotrexato Lederle
• Sodium methotrexate
• disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodium salt, L-(+)-
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2)

Methotrexate disodium salt, 98.5%

CAS: 7413-34-5

Methotrexate disodium salt, 7413-34-5, shows antineoplastic and immunosuppressive activities through inhibition of folic acid metabolism. Learn more at Thermo Fisher Scientific.

Formula: C₂₀H₂₀N₈Na₂O₅

Purity: 98.5%

Molecular weight: 498.41

Ref: 02-J66364

Methotrexate disodium salt

CAS: 7413-34-5

Formula: C₂₀H₂₀N₈Na₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 498.4029

Ref: IN-DA019FS7

Sodium (S)-2-(4-(((2,4-Diaminopteridin-6-Yl)Methyl)(Methyl)Amino)Benzamido)Pentanedioate

CAS: 7413-34-5

Sodium (S)-2-(4-(((2,4-Diaminopteridin-6-Yl)Methyl)(Methyl)Amino)Benzamido)Pentanedioate

Purity: 98%

Molecular weight: 498.4g/mol

Ref: 54-OR1026716

Methotrexate disodium

CAS: 7413-34-5

Methotrexate disodium

Purity: ≥98%

Molecular weight: 498.4g/mol

Ref: 54-BUP15911

Methotrexate disodium

CAS: 7413-34-5

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Formula: C₂₀H₂₀N₈Na₂O₅

Purity: 99.77% - 99.96%

Color and Shape: Solid

Molecular weight: 498.4

Ref: TM-T8003

Methotrexate Disodium Salt

Controlled Product

CAS: 7413-34-5

Applications Methotrexate Disodium Salt is a folic acid antagonist which is used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Formula: C₂₀H₂₀N₈Na₂O₅

Color and Shape: Neat

Molecular weight: 498.4

Ref: TR-M260753

Methotrexate Disodium

CAS: 7413-34-5

Formula: C₂₀H₂₀N₈O₅₂(Na)

Molecular weight: 452.43 : 2(22.99)

Ref: ST-EA-CP-M12054

Methotrexate disodium

CAS: 7413-34-5

Methotrexate is a drug that suppresses the immune system by inhibiting the production of white blood cells. It is used in the treatment of a number of diseases, including some cancers and autoimmune diseases such as rheumatoid arthritis and psoriasis. Methotrexate is metabolized to its active form, methotrexate, by an enzyme called dihydrofolate reductase (DHFR). The DHFR inhibitor activity of methotrexate blocks the synthesis of folate-dependent enzymes and prevents DNA synthesis in rapidly dividing cells. Methotrexate has been used in combination with other drugs to treat cancer. Methotrexate has also been shown to have antifungal properties against opportunistic fungal infections.

Formula: C₂₀H₂₀N₈Na₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 498.4 g/mol

Ref: 3D-FM148819