CAS 741713-40-6

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone

Description:

The chemical substance known as [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone, with the CAS number 741713-40-6, is a complex organic compound characterized by its multi-functional structure. It features a pyrimidine core substituted with an amino group and a piperidine moiety that contains a methylsulfonyl group, contributing to its potential biological activity. The presence of a difluoromethoxyphenyl group enhances its lipophilicity and may influence its interaction with biological targets. This compound is likely to exhibit properties relevant to medicinal chemistry, particularly in the context of drug development, due to its structural features that may interact with specific enzymes or receptors. Its synthesis and characterization would typically involve standard organic chemistry techniques, and it may be evaluated for pharmacological properties such as efficacy, selectivity, and toxicity in preclinical studies. As with many compounds of this nature, understanding its solubility, stability, and metabolic profile would be crucial for its application in therapeutic contexts.

Formula: C₁₈H₂₁F₂N₅O₄S

InChI: InChI=1/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)

SMILES: COc1ccc(c(c1C(=O)c1cnc(NC2CCN(CC2)S(=O)(=O)C)[nH]c1=N)F)F

Synonyms:

• R 547
• Ro 4584820
• (4-Amino-2-{[1-(Methylsulfonyl)Piperidin-4-Yl]Amino}Pyrimidin-5-Yl)(2,3-Difluoro-6-Methoxyphenyl)Methanone
• [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)
• [4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2
• 3-difluoro-6-Methoxyphenyl)-
• R547(Ro 4584820)
• 5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine
• [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
• (4-Amino-2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-5-pyrimidinyl)(2,3-difluoro-6-methoxyphenyl)methanone
• R547

R547

CAS: 741713-40-6

Formula: C₁₈H₂₁F₂N₅O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 441.4522

Ref: IN-DA00FC0X

R547

CAS: 741713-40-6

R547

Purity: ≥90%

Molecular weight: 441.45g/mol

Ref: 54-BUP09257

R547

CAS: 741713-40-6

R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.

Formula: C₁₈H₂₁F₂N₅O₄S

Purity: 90% - 99.64%

Color and Shape: Solid

Molecular weight: 441.45

Ref: TM-T6312

Ro 4584820

CAS: 741713-40-6

Inhibitor of cyclin-dependent kinases CDK1, CDK2, CDK4 and CDK7

Formula: C₁₈H₂₁F₂N₅O₄S

Purity: Min. 95%

Molecular weight: 441.45 g/mol

Ref: 3D-FR103426