CAS 742-20-1

Cyclopenthiazide

Description:

Cyclopenthiazide is a thiazide diuretic commonly used in the treatment of hypertension and edema. It is characterized by its chemical structure, which includes a benzothiadiazine ring fused with a cyclopentane moiety. This compound exhibits a sulfonamide functional group, contributing to its pharmacological activity. Cyclopenthiazide works by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, leading to increased excretion of sodium and water, thereby reducing blood volume and blood pressure. The substance is typically administered orally and is known for its relatively long duration of action. In terms of solubility, cyclopenthiazide is moderately soluble in water and more soluble in organic solvents, which influences its formulation in pharmaceutical preparations. As with many diuretics, potential side effects may include electrolyte imbalances, dehydration, and hypotension. Overall, cyclopenthiazide is an important medication in managing cardiovascular conditions, reflecting the broader class of thiazide diuretics in clinical use.

Formula: C₁₃H₁₈ClN₃O₄S₂

InChI: InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

InChI key: InChIKey=BKYKPTRYDKTTJY-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(CC3CCCC3)N1)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
• 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• 6-Chloro-3-cyclopentylmethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
• 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 6-chloro-3-cyclopentylmethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
• Benesal
• Ciba 8341-Su
• Cyclomethiazide
• Cyclometiazid
• Cyclopentiazid
• NSC 107679
• Navidreks
• Navidrex
• Navidrix
• Salimed
• Salimid
• Salurilo-C
• Su 8341
• Tsiklometiazid
• Ultra-Minzil

Cyclopenthiazide

CAS: 742-20-1

Cyclopenthiazide

Color and Shape: Off White Solid

Ref: 47-98

2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide

CAS: 742-20-1

Formula: C₁₃H₁₈ClN₃O₄S₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 379.8827

Ref: IN-DA01CBA9

Cyclopenthiazide

CAS: 742-20-1

Cyclopenthiazide

Purity: ≥98%

Molecular weight: 379.88g/mol

Ref: 54-BUP21420

Cyclopenthiazide

CAS: 742-20-1

Formula: C₁₃H₁₈ClN₃O₄S₂

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 379.87

Ref: 3B-C3958

Cyclopenthiazide

CAS: 742-20-1

Cyclopenthiazide is a thiazide diuretic for hypertension, heart failure; lowers calcium, uric acid, raises sodium, potassium loss.

Formula: C₁₃H₁₈ClN₃O₄S₂

Purity: 99.47%

Color and Shape: Crystals

Molecular weight: 379.88

Ref: TM-T21469

Cyclopenthiazide

CAS: 742-20-1

Applications Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
References Davila, D. et al.: Acta Biol. Med. Exp., 5, 1(1980); Frenzel, J. et al.: Acta Paed. Acad. Sci. Hing., 15, 157 (1974); Takamura, N. et al.: Pharmac. Res., 11, 1452 (1994);

Formula: C₁₃H₁₈ClN₃O₄S₂

Color and Shape: Neat

Molecular weight: 379.88

Ref: TR-C988420

Cyclopenthiazide-d9

Controlled Product

CAS: 742-20-1

Formula: C₁₃D₉H₉ClN₃O₄S₂

Color and Shape: Neat

Molecular weight: 388.938

Ref: TR-C988422