CAS 7421-40-1

Carbenoxolone sodium

Description:

Carbenoxolone sodium is a synthetic derivative of glycyrrhizin, primarily known for its anti-inflammatory and ulcer-healing properties. It is often used in the treatment of gastrointestinal disorders, particularly peptic ulcers and oral mucositis. The compound functions by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase, which leads to increased local concentrations of glucocorticoids, thereby exerting its therapeutic effects. Carbenoxolone sodium is typically administered in the form of a sodium salt, enhancing its solubility and bioavailability. The substance is characterized by its ability to promote mucosal healing and reduce inflammation, making it valuable in clinical settings. Additionally, it has been studied for its potential effects on various cellular processes, including its influence on cell proliferation and apoptosis. While generally well-tolerated, it may have side effects, particularly with prolonged use, such as electrolyte imbalances. As with any medication, it is essential to use carbenoxolone sodium under medical supervision to monitor for adverse effects and interactions with other treatments.

Formula: C₃₄H₅₀O₇·2Na

InChI: InChI=1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/t21-,23-,24-,27+,30+,31-,32-,33+,34+;;/m0../s1

InChI key: InChIKey=OUNBBVKBERWKFE-SBBGFIFASA-N

SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](OC(CCC(O)=O)=O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H].[Na]

Synonyms:

• 3-(Succinyloxy)glycyrrhetic acid disodium salt
• Bioral
• Carbenoxalone disodium salt
• Carbenoxalone sodium
• Carbenoxolone disodium salt
• Carbenoxolone sodium
• Carbenoxolone sodium salt
• Disodium (3Beta)-3-[(3-Carboxylatopropanoyl)Oxy]-11-Oxoolean-12-En-30-Oate
• Disodium (3Beta,8Xi,10Xi,17Xi,18Xi)-3-[(3-Carboxylatopropanoyl)Oxy]-11-Oxoolean-12-En-30-Oate
• Disodium 4-(20-Carboxylato-11-Oxo-30-Beta-Norolean-12-En-3-Yloxy)-4-Oxobutyrate
• Disodium glycyrrhetic acid hemisuccinate
• Disodium glycyrrhetinyl succinate
• Duogastrone
• Glycyrrhetic acid hydrosuccinate disodium salt
• Glycyrrhetinic acid hydrogen succinate disodium salt
• Glycyrrhetinic acid succinate disodium salt
• Neogel
• Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, disodium salt, (3β,20β)-
• Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, sodium salt (1:2), (3β,20β)-
• Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-, hydrogen succinate, disodium salt
• Pyrogastrone
• Sanodin
• Sodium carbenoxolone

Carbenoxolone disodium salt, 97+%

CAS: 7421-40-1

Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 -hydroxysteroid dehydrogenase (human) and 3, 20 -hydroxysteroid dehydrogenase (bacterial). It is used for the treatmen

Formula: C₃₄H₄₈Na₂O₇

Purity: 97+%

Color and Shape: White to pale cream, Powder

Molecular weight: 614.73

Ref: 02-J63714

Carbenoxolone (sodium salt)

CAS: 7421-40-1

Formula: C₃₄H₄₈Na₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 614.7203

Ref: IN-DA003OP7

Carbenoxolone disodium

CAS: 7421-40-1

Carbenoxolone disodium

Purity: ≥98%

Molecular weight: 614.72g/mol

Ref: 54-BUP13551

Carbenoxolone Disodium

CAS: 7421-40-1

Formula: C₃₄H₄₈O₇·2Na

Molecular weight: 568.75 2 22.99

Ref: 4Z-C-326001

Carbenoxolone disodium

CAS: 7421-40-1

Carbenoxolone disodium treats stomach ulcers; derived from licorice, often has antidiuretic effects, low toxicity.

Formula: C₃₄H₄₈Na₂O₇

Purity: 99.69%

Color and Shape: Solid

Molecular weight: 614.72

Ref: TM-T0992

Carbenoxolone Disodium

Controlled Product

CAS: 7421-40-1

Applications Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative.
References Rask-Madsen, J., et al.: Eur. J. Clin.Invest., 13, 351 (1983), Minuz, P., et al.: Pharmacol. Res. Commun., 16, 875 (1984), Pindato, S., et al.: Anal. Profiles Drug Subs. Excip., 24, 1 (1996),

Formula: C₃₄H₄₈O₇·2Na

Color and Shape: Neat

Molecular weight: 614.72

Ref: TR-C175885

Carbenoxolone disodium

Controlled Product

CAS: 7421-40-1

Carbenoxolone disodium is a glycol ester that inhibits the P2Y receptor in microglial cells and astrocytes. It has been shown to have anti-inflammatory effects on the central nervous system by inhibiting the production of pro-inflammatory cytokines. Carbenoxolone sodium, which is a related compound, was shown to have protective effects in mouse models of autoimmune diseases. This drug also protects against neuronal death induced by seizure activity and autophagy induced by starvation. Carbenoxolone disodium has been shown to cause cardiac toxicity and liver damage when administered at high doses.

Formula: C₃₄H₄₈Na₂O₇

Purity: Min. 95%

Molecular weight: 614.72 g/mol

Ref: 3D-FC19690