CAS 7423-93-0

3-Chloro-L-tyrosine

Description:

3-Chloro-L-tyrosine is a halogenated derivative of the amino acid tyrosine, characterized by the presence of a chlorine atom at the meta position of the aromatic ring. This compound is typically classified as a non-proteinogenic amino acid, meaning it is not incorporated into proteins during translation. It exhibits properties similar to those of L-tyrosine, including the ability to participate in various biochemical reactions, but the chlorine substitution can influence its reactivity and interactions with enzymes and receptors. 3-Chloro-L-tyrosine is often studied for its potential roles in biochemical pathways, particularly in the synthesis of neurotransmitters and other biologically active molecules. Additionally, it may serve as a useful tool in research related to protein structure and function, as well as in the development of pharmaceuticals. The compound is soluble in polar solvents, and its stability can be affected by environmental conditions such as pH and temperature. As with many halogenated compounds, safety precautions should be taken when handling 3-Chloro-L-tyrosine due to potential toxicity and environmental impact.

Formula: C₉H₁₀ClNO₃

InChI: InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

InChI key: InChIKey=ACWBBAGYTKWBCD-ZETCQYMHSA-N

SMILES: C([C@@H](C(O)=O)N)C1=CC(Cl)=C(O)C=C1

Synonyms:

• (2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid
• 2: PN: WO2005055810 PAGE: 59 claimed protein
• 3-Chloro-4-hydroxy-L-phenylalanine~H-Tyr(3-Cl)-OH
• 3-Chloro-<span class="text-smallcaps">L</span>-tyrosine
• 3-Chlorotyrosine
• <span class="text-smallcaps">L</span>-Tyrosine, 3-chloro-
• H-Tyr(3-Cl)-OH
• Monochlorotyrosine
• Tyrosine, 3-chloro-, <span class="text-smallcaps">L</span>-
• L-Tyrosine, 3-chloro-
• 3-Chloro-L-tyrosine

3-Chlorotyrosine

CAS: 7423-93-0

Formula: C₉H₁₀ClNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 215.6336

Ref: IN-DA00ICI2

3-Chloro-L-tyrosine

CAS: 7423-93-0

Formula: C₉H₁₀ClNO₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 215.64

Ref: 7W-GM4001

(2S)-2-Amino-3-(3-chloro-4-hydroxy-phenyl)propanoic acid

CAS: 7423-93-0

(2S)-2-Amino-3-(3-chloro-4-hydroxy-phenyl)propanoic acid

Purity: 98%

Molecular weight: 215.63g/mol

Ref: 54-OR480459

H-Tyr(3-Cl)-OH

CAS: 7423-93-0

Formula: C₉H₁₀ClNO₃

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 215.63

Ref: 3B-C3770

3-Chloro-L-Tyrosine

CAS: 7423-93-0

3-Chloro-L-Tyrosine (Chlorotyrosine), a marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in LDL isolated from human atherosclerotic intima.

Formula: C₉H₁₀ClNO₃

Purity: 98.18% - 98.68%

Color and Shape: Solid

Molecular weight: 215.63

Ref: TM-T5280

3-Chloro-L-tyrosine

Controlled Product

CAS: 7423-93-0

Stability Hygroscopic
Applications 3-Chloro-L-tyrosine was used in the enzymatic synthesis of halogen derivatives of aromatic amino acids labeled with hydrogen isotope. 3-Chloro-L-tyrosine exhibited stronger antioxidant properties in Hb-induced oxidative stress as was evident by higher efficiency of reduction of ferryl species.
References Winnicka, E., et al.: J. Chem. Eng., 8, 54 (2014); Lu, N., et al.: Toxicol. In Vitro, 28, 847 (2014);

Formula: C₉H₁₀NO₃Cl

Color and Shape: Neat

Molecular weight: 215.63

Ref: TR-C423100

3-Chloro-L-tyrosine

CAS: 7423-93-0

3-Chloro-L-tyrosine (3CT) is a reactive, nitrogen containing molecule that has been used as a model system to study oxidative injury in the heart. The molecule reacts with the air and oxygen in the environment, producing reactive oxygen species (ROS) that can cause oxidative injury. 3CT has been shown to inhibit ATP binding cassette transporter A1 (ABCA1), which is involved in cholesterol efflux from macrophages. 3CT also promotes the release of eosinophil peroxidase from eosinophils and induces tumor necrosis factor alpha (TNF-α). The analytical method for 3CT includes liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS).

Formula: C₉H₁₀NO₃Cl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 215.63 g/mol

Ref: 3D-FC48379

3-Chloro-L-tyrosine

CAS: 7423-93-0

M06094 - 3-Chloro-L-tyrosine

Formula: C₉H₁₀ClNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 215.63

Ref: 10-M06094