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CAS 74258-86-9

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Alacepril

Description:
Alacepril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical structure of Alacepril includes a carboxyl group and a proline derivative, which contribute to its pharmacological activity. It is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include dizziness, cough, and elevated potassium levels, similar to other ACE inhibitors. Alacepril is often used in combination with other antihypertensive agents to enhance therapeutic efficacy. As with other medications in its class, caution is advised in patients with renal impairment or those who are pregnant, due to potential adverse effects on fetal development. Overall, Alacepril represents a valuable option in the management of cardiovascular conditions.
Formula:C20H26N2O5S
InChI:InChI=1S/C20H26N2O5S/c1-13(12-28-14(2)23)19(25)22-10-6-9-17(22)18(24)21-16(20(26)27)11-15-7-4-3-5-8-15/h3-5,7-8,13,16-17H,6,9-12H2,1-2H3,(H,21,24)(H,26,27)/t13-,16+,17+/m1/s1
InChI key:InChIKey=FHHHOYXPRDYHEZ-COXVUDFISA-N
SMILES:C([C@@H](CSC(C)=O)C)(=O)N1[C@H](C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)CCC1
Synonyms:
  • 1-[(2S)-3-(Acetylthio)-2-methyl-1-oxopropyl]-<span class="text-smallcaps">L</smallcap>-prolyl-<smallcap>L</span>-phenylalanine
  • 1-[(2S)-3-(acetylsulfanyl)-2-methylpropanoyl]-L-prolyl-L-phenylalanine
  • 1-[3-(Acetylsulfanyl)-2-Methylpropanoyl]Prolylphenylalanine
  • <span class="text-smallcaps">L</smallcap>-Phenylalanine, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-<smallcap>L</span>-prolyl-
  • <span class="text-smallcaps">L</smallcap>-Phenylalanine, N-[1-[3-(acetylthio)-2-methyl-1-oxopropyl]-<smallcap>L</span>-prolyl]-, (S)-
  • Cetapril
  • Du 1219
  • Phenylalanine, 1-[3-(Acetylthio)-2-Methyl-1-Oxopropyl]Prolyl-
  • L-Phenylalanine, N-[1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-, (S)-
  • 1-[(2S)-3-(Acetylthio)-2-methyl-1-oxopropyl]-L-prolyl-L-phenylalanine
  • See more synonyms
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Found 5 products.