CAS 74356-00-6

Cefotetan disodium

Description:

Cefotetan disodium is a broad-spectrum cephalosporin antibiotic used primarily for the treatment of various bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria, making it a valuable option in clinical settings. The compound is characterized by its disodium salt form, which enhances its solubility in aqueous solutions, facilitating intravenous administration. Cefotetan works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is particularly noted for its activity against anaerobic bacteria, which makes it useful in surgical prophylaxis and the treatment of intra-abdominal infections. The substance is typically administered via injection, and its pharmacokinetics include a relatively short half-life, necessitating multiple doses for sustained therapeutic effect. Common side effects may include gastrointestinal disturbances, allergic reactions, and potential interactions with other medications. As with all antibiotics, appropriate use is crucial to prevent the development of antibiotic resistance. Overall, cefotetan disodium is an important tool in the arsenal against bacterial infections, particularly in hospital settings.

Formula: C₁₇H₁₅N₇Na₂O₈S₄

InChI: InChI=1/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15?,17-;;/m0../s1

InChI key: InChIKey=LUEJDHJZJQWQLM-ZTQQJVKJSA-N

SMILES: N(C(=O)C1SC(=C(C(N)=O)C(O)=O)S1)[C@@]2(OC)[C@@]3(N(C2=O)C(C(O)=O)=C(CSC=4N(C)N=NN4)CS3)[H].[Na]

Synonyms:

• 1,3-Dithietane, 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid deriv.
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, disodium salt, (6R,7S)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, disodium salt, [6R-(6α,7α)]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, sodium salt (1:2), (6R,7S)-
• Apatef
• Cefotan
• Cefotetan Disodium
• Ceftenon
• Cepan Darvilen
• Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Yamatetan
• Ym 09330
• disodium (6R,7S)-7-({[4-(2-amino-1-carboxylato-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• disodium (7S)-7-({[4-(2-amino-1-carboxylato-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-aMino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7S)-
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, disodium salt, (6R-(6alpha,7alpha))-
• Cefotetan disodi
• Cefotan in plastic container
• Cefotetan and dextrose in duplex container

Cefotetan disodium

CAS: 74356-00-6

A broad spectrum antibiotic

Formula: C₁₇H₁₅N₇Na₂O₈S₄

Molecular weight: 619.58

Ref: 02-J66206

Cefotetan disodium salt

CAS: 74356-00-6

Formula: C₁₇H₁₅N₇Na₂O₈S₄

Purity: 840 - 930 μg/mg (C17H15N7O8S4)

Color and Shape: White, off-white, light-yellow or beige powder

Molecular weight: 619.58

Ref: 7W-GA5476

Cefotetan disodium

CAS: 74356-00-6

Cefotetan Sodium: a 2nd-gen cephamycin antibiotic effective against various aerobic/anaerobic, gram+/- bacteria, inhibits cell wall synthesis.

Formula: C₁₇H₁₅N₇Na₂O₈S₄

Color and Shape: Solid

Molecular weight: 619.57

Ref: TM-T21400

Cefotetan disodium

CAS: 74356-00-6

Formula: C₁₇H₁₅N₇O₈S₄·2Na

Molecular weight: 573.59 2 22.99

Ref: 4Z-C-243002

Cefotetan Disodium Salt

CAS: 74356-00-6

Cefotetan Disodium Salt

Formula: C₁₇H₁₅N₇O₈S₄·2Na

Purity: By hplc: 89-90% (Typical Value in Batch COA)

Color and Shape: off white to light beige powder

Molecular weight: 619.58g/mol

Ref: 54-BIC0105

Cefotetan disodium

CAS: 74356-00-6

Inhibitor of cell wall synthesis; cephalosporin class

Formula: C₁₇H₁₅N₇Na₂O₈S₄

Purity: Min. 85 Area-%

Color and Shape: Powder

Molecular weight: 619.59 g/mol

Ref: 3D-AD41176

Cefotetan Disodium Salt extrapure, 85%

CAS: 74356-00-6

Formula: C₁₇H₁₅N₇Na₂O₈S₄

Molecular weight: 619.59

Ref: SR-26732

Cefotetan disodium

CAS: 74356-00-6

Formula: C₁₇H₁₅N₇O₈S₄Na

Molecular weight: 573.59 : 2(22.99)

Ref: ST-EA-CP-C378004