CAS 74362-46-2

imidazole-15N2

Description:

Imidazole-15N2, with the CAS number 74362-46-2, is a nitrogen-containing heterocyclic compound characterized by its five-membered ring structure that includes two nitrogen atoms. This compound is a labeled isotope of imidazole, where the nitrogen atoms are isotopically enriched with nitrogen-15 (15N), making it useful in various applications, particularly in biochemical and pharmaceutical research. Imidazole itself is known for its role in biological systems, notably as a component of histidine, an essential amino acid. The presence of the 15N isotopes allows for enhanced tracking and analysis in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, facilitating studies on metabolic pathways and protein interactions. Imidazole derivatives are often utilized in the synthesis of pharmaceuticals, agrochemicals, and as ligands in coordination chemistry. The compound is typically stable under standard conditions but may undergo reactions characteristic of imidazole, such as protonation and nucleophilic substitution, depending on the surrounding environment.

Formula: C₃H₄₁₅N₂

InChI: InChI=1/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)/i4+1,5+1

Imidazole-15N2

Controlled Product

CAS: 74362-46-2

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Formula: C₃H₄₁₅N₂

Color and Shape: Neat

Molecular weight: 70.06

Ref: TR-I350202

Imidazole-15N2

CAS: 74362-46-2

Imidazole-15N2 is an analog of the calcium channel blocker nifedipine that has been shown to have anticancer properties. It induces apoptosis in cancer cells by inhibiting protein kinases, which are involved in tumor growth and survival. Imidazole-15N2 has been studied in both Chinese hamster ovary cells and human cancer cell lines, where it has demonstrated potent inhibition of kinase activity. This drug is a promising candidate for the development of novel cancer therapies due to its ability to selectively target cancer cells while sparing normal cells. Imidazole-15N2 can be detected in urine and may serve as a biomarker for the presence of protein kinase inhibitors in the body.

Formula: C₃H₄N₂

Purity: Min. 95%

Molecular weight: 70.06 g/mol

Ref: 3D-ZCA36246