CAS 74381-53-6

Leuprolide acetate

Description:

Leuprolide acetate is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) and is classified as a gonadotropin-releasing hormone agonist. It is primarily used in the treatment of hormone-sensitive conditions such as prostate cancer, endometriosis, and precocious puberty. The substance functions by initially stimulating the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary increase in sex hormone levels. However, with continuous administration, it downregulates GnRH receptors, resulting in decreased production of sex hormones. Leuprolide acetate is typically administered via injection and is known for its prolonged action due to its acetate formulation, which enhances its stability and bioavailability. The compound is characterized by its specific molecular structure, which includes a sequence of amino acids that contribute to its biological activity. Common side effects may include hot flashes, decreased libido, and mood changes, reflecting its impact on hormonal balance. Overall, leuprolide acetate is a crucial therapeutic agent in managing various hormone-dependent disorders.

Formula: C₆₁H₈₈N₁₆O₁₄

InChI: InChI=1/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)/t40-,41-,42-,43+,44-,45-,46-,47-,48-;/m0./s1

Synonyms:

• 5-Oxo-L-prolil-L-histidil-L-tryptophil-L-seril-L-thyrozil-D-leucil-L-arginil-N-ethyl-L-prolinamide acetate
• Leuprorelin Acetate
• 5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-N~5~-(diaminomethylidene)ornithyl-N-ethylprolinamide acetate (1:1)
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-N-ethyl-L-prolinamide acetate (1:1)

Leuprorelin Acetate

CAS: 53714-56-0, 74381-53-6

Formula: C₅₉H₈₄N₁₆O₁₂·C₂H₄O₂

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 1,269.47

Ref: 3B-L0249

(Des-Gly¹⁰,D-Leu⁶,Pro-NHEt⁹)-LHRH

CAS: 74381-53-6

Leuprolide, a highly active LHRH (GnRH) agonist stimulates the pituitary release of luteinizing hormone, causing an increase in testicular androgen production. Thus, leuprolide represents a safer alternative to estrogens, and may be preferred in the treatment of men with advanced prostate cancer. CAS Number (net): 53714-56-0.

Formula: C₅₉H₈₄N₁₆O₁₂

Purity: 98.9%

Color and Shape: White Lyophilisate

Molecular weight: 1209.42

Ref: 01-4033014

LEUPRORELIN CRS

CAS: 74381-53-6

LEUPRORELIN CRS

Formula: C₅₉H₈₄N₁₆O₁₂

Color and Shape: Added Modified

Molecular weight: 1209.398

Ref: 41-L0376000

Leuprolide Acetate

CAS: 74381-53-6

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₅₉H₈₄N₁₆O₁₂·(C₂H₄O₂)n

Color and Shape: White Off-White Flocculent Powder

Molecular weight: 1208.64546

Ref: 45-1358503

Leuprorelin (acetate)

CAS: 74381-53-6

Formula: C₆₁H₈₈N₁₆O₁₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 1269.4502

Ref: IN-DA0039VT

Leuprolide acetate

CAS: 74381-53-6

Formula: C₅₉H₈₄N₁₆O₁₂·xC₂H₄O₂

Purity: 97.0 - 103.0 % (anhydrous, acetic acid free basis)

Color and Shape: White to almost white powder

Molecular weight: 1209.40 (base)

Ref: 7W-GP2433

Leuprorelin Acetate

CAS: 74381-53-6

Formula: C₆₁H₈₈N₁₆O₁₄

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1269.45

Ref: BP-BPPG044

Leuprorelin (Leuprolide) Acetate

CAS: 74381-53-6

Formula: C₅₉H₈₄N₁₆O₁₂·C₂H₄O₂

Molecular weight: 1209.42 60.05

Ref: 4Z-PL-4134

Leuprorelin Acetate RS

CAS: 74381-53-6

Color and Shape: White Solid Powder

Ref: 2K-1183100021

Leuprolide-d5 Acetate

Controlled Product

CAS: 74381-53-6

Applications Labelled synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
References Vilchez-Martinez, J.A., et al.: Biochem. Biophys. Res. Commun., 59, 1226 (1974), Sennello, L.T., et al.: J. Pharm. Sci., et al.: 75, 158 (1986), Wheeler, J.M., et al.: Am.J. Obstet. Gynecol., 167, 1367 (1992), Eri, L.M., et al.: J. Urol., 150, 359 (1993),

Formula: C₅₉H₇₉D₅N₁₆O₁₂•x(C₂H₄O₂)

Color and Shape: Neat

Molecular weight: 1214.456005

Ref: TR-L330602

Leuprolide acetate

Controlled Product

CAS: 74381-53-6

Agonist of GnRH receptors

Formula: C₆₁H₈₈N₁₆O₁₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,269.47 g/mol

Ref: 3D-FL24877