CAS 74389-68-7

Platelet-activating factor

Description:

Platelet-activating factor (PAF), with the CAS number 74389-68-7, is a phospholipid mediator that plays a crucial role in various physiological and pathological processes. It is a potent bioactive lipid that is primarily involved in inflammation, thrombosis, and allergic responses. PAF is characterized by its ability to activate platelets, leading to aggregation and the release of various mediators. Structurally, it is an ether-linked phospholipid, which distinguishes it from other phospholipids. PAF is synthesized from membrane phospholipids by the action of specific enzymes, such as phospholipase A2. Its biological effects are mediated through specific receptors, known as PAF receptors, which are widely distributed in various tissues. PAF is also implicated in several diseases, including asthma, cardiovascular disorders, and sepsis, making it a target for therapeutic interventions. Due to its potent effects at very low concentrations, PAF is considered a significant signaling molecule in both health and disease.

Formula: C₂₆H₅₄NO₇P

InChI: InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

InChI key: InChIKey=HVAUUPRFYPCOCA-AREMUKBSSA-N

SMILES: [C@H](COP(OCC[N+](C)(C)C)(=O)[O-])(COCCCCCCCCCCCCCCCC)OC(C)=O

Synonyms:

• (2R)-2-Acetoxy-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate
• 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
• 1-O-Hexadecyl-2-Acetyl-Sn-Glycero-3-Phosphocholine
• 1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine
• 1-O-Hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine
• 1-O-Hexadecyl-2-acetyl-sn-glycerophosphocholine
• 1-O-Hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
• 1-O-Hexadecyl-platelet-activating factor
• 3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (7R)-
• 3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-
• Blood platelet-activating factor
• Blood platelet-activating factor acether
• C₁₆-PAF
• C₁₆-PAF acether
• Ethanaminium, 2-[[[[(2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
• PAF acether
• Paf 16
• Paf C 16
• Platelet-activating factor
• Platelet-activating factor (1-O-hexadecyl)

1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine

CAS: 74389-68-7

Accelerated cognitive decline in Alzheimer’s patients is associated with accumulation of choline-containing phospholipids. One of them, C16-PAF, is specifically elevated in brains of Alzheimer’s patients. Enhanced exposure to this platelet-activating factor ultimately leads to neuronal death.

Formula: C₂₆H₅₄NO₇P

Purity: > 99%

Color and Shape: White

Molecular weight: 523.69

Ref: 01-4006552

3,5,9-Trioxa-4-phosphapentacosan-1-aminium,7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (7R)-

CAS: 74389-68-7

Formula: C₂₆H₅₄NO₇P

Purity: 98%

Molecular weight: 523.6832

Ref: IN-DA00FA7U

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine

CAS: 74389-68-7

Formula: C₂₆H₅₄NO₇P

Molecular weight: 523.68

Ref: 7W-GL9539

PAF (C16)

Controlled Product

CAS: 74389-68-7

Formula: C₂₆H₅₄NO₇P

Color and Shape: Neat

Molecular weight: 523.683

Ref: TR-P133885

PAF (C16)

CAS: 74389-68-7

PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.

Formula: C₂₆H₅₄NO₇P

Purity: 98%

Color and Shape: Solid

Molecular weight: 523.68

Ref: TM-T21547

PAF (C16)

CAS: 74389-68-7

PAF, short for Platelet-activating factor, is a mediator of platelet aggregation and a ligand for PAF receptors. It has roles in many other leukocyte functions around inflammation and immune response, as well as, chemotaxis and vasuclar changes. The PAF signaling system can trigger significant inflammatory and thrombotic cascades, and has been show to have roles in septic shock.

Formula: C₂₆H₅₄NO₇P

Purity: Min. 95%

Molecular weight: 523.68 g/mol

Ref: 3D-ZCA38968