CAS 74389-69-8

1-O-Octadecyl-platelet-activating factor

Description:

1-O-Octadecyl-platelet-activating factor (PAF) is a synthetic analog of platelet-activating factor, a potent phospholipid mediator involved in various biological processes, including inflammation and thrombosis. This compound features a long-chain octadecyl group, which enhances its lipophilicity and membrane permeability. Its structure typically includes an acetyl group at the sn-2 position, contributing to its biological activity. The presence of the octadecyl chain allows for increased interaction with cell membranes, potentially influencing cellular signaling pathways. 1-O-Octadecyl-PAF is often used in research to study the mechanisms of PAF action and its role in various physiological and pathological processes. It may exhibit pro-inflammatory effects and can modulate immune responses. Additionally, due to its structural similarity to natural PAF, it can serve as a valuable tool in pharmacological studies aimed at understanding PAF-related signaling pathways. Safety and handling precautions should be observed, as with any bioactive compound, due to its potential effects on biological systems.

Formula: C₂₈H₅₈NO₇P

InChI: InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1

InChI key: InChIKey=ZXCIEWBDUAPBJF-MUUNZHRXSA-N

SMILES: [C@H](COP(OCC[N+](C)(C)C)(=O)[O-])(COCCCCCCCCCCCCCCCCCC)OC(C)=O

Synonyms:

• (2R)-2-(acetyloxy)-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate
• (R)-2-Acetoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
• 1-O-Octadecyl-2-O-acetyl-sn-glycerol-3-phosphorylcholine
• 1-O-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine
• 1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
• 1-O-Octadecyl-platelet-activating factor
• 1-O-Stearyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
• 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (7R)-
• 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-
• Blood platelet activating factor-acether
• Blood platelet-activating factor
• C₁₈-PAF
• C₁₈-PAF-acether
• PAF acether
• Platelet activating factor-acether
• Platelet-activating factor
• Platelet-activating factor (1-O-octadecyl)

PAF (C18)

CAS: 74389-69-8

Formula: C₂₈H₅₈NO₇P

Purity: 99%

Molecular weight: 551.7364

Ref: IN-DA00FA7T

PAF C-18

CAS: 74389-69-8

PAF C-18 is a natural phospholipid molecule belonging to the platelet-activating factor (PAF) family,, involved in hemostasis and thrombosis by binding to PAFR.

Formula: C₂₈H₅₈NO₇P

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 551.74

Ref: TM-T36763

1-O-Octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine

CAS: 74389-69-8

1-O-Octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (OGPC) is a phospholipid that has been shown to be an effective drug in the treatment of chronic arthritis. It is a potent antagonist of the inflammatory response, and has been shown to inhibit the production of inflammatory cytokines such as tumour necrosis factor alpha (TNFα). OGPC has been used in cell culture studies, which have shown that it inhibits IL2 receptor binding and TNFα release by human monocytes. Clinical studies have also shown that OGPC can be used to treat arthritis.

Formula: C₂₈H₅₈NO₇P

Purity: Min. 95%

Molecular weight: 551.74 g/mol

Ref: 3D-FO111145