CAS 74392-49-7

H-D-Phe-Phe-Arg-chloromethylketone

Description:

H-D-Phe-Phe-Arg-chloromethylketone, also known as a chloromethyl ketone derivative, is a synthetic compound often utilized in biochemical research, particularly in the study of proteases and enzyme inhibition. This compound features a chloromethyl ketone functional group, which is known for its reactivity, allowing it to form covalent bonds with nucleophilic sites in proteins, thereby inhibiting their activity. The presence of the amino acid residues, specifically phenylalanine (Phe) and arginine (Arg), suggests that it may interact with specific biological targets, potentially influencing protein structure and function. The compound is typically used in laboratory settings and may require careful handling due to its reactive nature. As with many synthetic peptides and derivatives, it is important to consider its stability, solubility, and potential biological effects when designing experiments. Safety data sheets should be consulted for proper handling and disposal procedures.

Formula: C₂₅H₃₃ClN₆O₃

InChI: InChI=1/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-24(35)21(15-18-10-5-2-6-11-18)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21H,7,12-16,27H2,(H,31,35)(H,32,34)(H4,28,29,30)/t19-,20+,21+/m1/s1

Synonyms:

• Phenylalanyl-phenylalanyl-arginine chloromethyl ketone
• D-Phe-phe-arg-CH2Cl
• D-Phe-phe-arg-chloromethyl ketone
• Dppacmk
• Ffrck
• Phe-phe-arg-CH2-Cl
• Phe-phe-arg-CK
• Phe-phe-arg-chloromethyl ketone
• L-Phenylalaninamide, D-phenylalanyl-N-(4-((aminoiminomethyl)amino)-1-(chloroacetyl)butyl)-, (S)-
• (2R)-2-amino-N-[(2S)-2-({(3S)-1-chloro-6-[(diaminomethylidene)amino]-2-oxohexan-3-yl}amino)-3-phenylpropanoyl]-3-phenylpropanamide (non-preferred name)
• D-phenylalanyl-N-{(3S)-1-chloro-6-[(diaminomethylidene)amino]-2-oxohexan-3-yl}-L-phenylalaninamide

H-D-Phe-Phe-Arg-chloromethylketone

CAS: 74392-49-7

Kallikrein inhibitor which is even effective in preventing apolipoprotein B-100 proteolysis in dextran sulfate (DS)-precipitated human plasma low density lipoproteins (LDL). D-FFR-CMK also inhibits gingipain R.

Formula: C₂₅H₃₃ClN₆O₃

Purity: 96.3%

Color and Shape: White

Molecular weight: 501.03

Ref: 01-4014271

PPACK II

CAS: 74392-49-7

PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .

Formula: C₂₅H₃₃ClN₆O₃

Color and Shape: Solid

Molecular weight: 501.02

Ref: TM-T73863