CAS 7444-29-3

Anhydroleucovorin

Description:

Anhydroleucovorin, with the CAS number 7444-29-3, is a chemical compound that serves as a derivative of leucovorin, which is a form of folate (vitamin B9). It is primarily used in medical applications, particularly in the treatment of certain types of cancer and in the management of methotrexate toxicity. Anhydroleucovorin is characterized by its ability to act as a cofactor in various biochemical reactions, particularly those involving the synthesis of nucleic acids and amino acids. This compound is typically administered in a clinical setting and is known for its role in enhancing the efficacy of chemotherapy agents while mitigating their side effects. Its stability and solubility in aqueous solutions are important for its therapeutic applications. As with many pharmaceuticals, the handling and administration of anhydroleucovorin require careful consideration of dosage and potential interactions with other medications. Overall, its significance in oncology and pharmacology underscores the importance of folate derivatives in medical treatments.

Formula: C₂₀H₂₁N₇O₆

InChI: InChI=1/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p+1/t12-,13+/m1/s1

InChI key: InChIKey=MEANFMOQMXYMCT-OLZOCXBDSA-N

SMILES: O=C1C=2N3[C@@](C[N+](=C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C([O-])=O)=O)C=C4)(CNC2NC(N)=N1)[H]

Synonyms:

• (2S)-2-({4-[(6aR)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydro-8H-imidazo[1,5-f]pteridin-10-ium-8-yl]benzoyl}amino)-4-carboxybutanoate
• 1H-Imidazo[1,5-f]pteridin-10-ium, 3-amino-8-[p-[(1,3-dicarboxypropyl)carbamoyl]phenyl]-2,5,6,6a,7,8-hexahydro-1-oxo-, hydroxide, inner salt
• 3-Amino-8-[p-[(1,3-dicarboxypropyl)carbamoyl]phenyl]-1,2,5,6,6a,7-hexahydro-1-oxo-8H-imidazo[1,5-f]pteridin-10-ium hydroxide, inner salt
• 3-Amino-8-[p-[(<span class="text-smallcaps">L</span>-1,3-dicarboxypropyl)carbamoyl]phenyl]-1,2,5,6,6a,7-hexahydro-1-oxo-8H-imidazo[1,5-f]pteridin-10-ium hydroxide, inner salt
• 5,10-Methenyltetrahydrofolate
• 5,10-Methenyltetrahydropteroylglutamate
• Anhydroleucovorin
• Anhydroleucovorin A
• Imidazo(1,5-f)pteridinium, 3-amino-8-(4-(((1,3-dicarboxypropyl)amino)carbonyl)phenyl)-1,2,5,6,6a,7-hexahydro-1-oxo-, inner salt
• Imidazo[1,5-f]pteridinium, 3-amino-8-[4-[[(1,3-dicarboxypropyl)amino]carbonyl]phenyl]-1,2,5,6,6a,7-hexahydro-1-oxo-, inner salt, [R-(R*,S*)]-
• Imidazo[1,5-f]pteridinium, 3-amino-8-[4-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]phenyl]-1,2,5,6,6a,7-hexahydro-1-oxo-, inner salt, (6aR)-
• Leucovorin A, anhydro-
• Leucovorin, anhydro-
• N-[4-(3-amino-1-hydroxy-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8-ium-8-yl)benzoyl]glutamic acid
• N-{4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydro-8H-imidazo[1,5-f]pteridin-10-ium-8-yl]benzoyl}-L-glutamic acid
• 3-Amino-8-[p-[(L-1,3-dicarboxypropyl)carbamoyl]phenyl]-1,2,5,6,6a,7-hexahydro-1-oxo-8H-imidazo[1,5-f]pteridin-10-ium hydroxide, inner salt
• Folinic Acid Impurity 9
• Calcium Levofolinate Impurity 3
• Anhydro leucovorin, 5,10-methenyltetrahydrofolate
• Anhydro leucovorin, 5,10-Methenyltetrahydrofolate API
• (2S)-2-(4-(3-amino-1-oxo-1,4,5,6,6a,7
• Anhydro leucovorin
• Methenyltetrahydrofolic Acid
• 10-Formyltetrahydropteroylglutamic acid
• Imidazo[1,5-f]pteridinium, 3-amino-8-[4-[[(1,3-dicarboxypropyl)amino]c arbonyl]phenyl]-1,2,5,6,6a,7-hexahydro-1-oxo-, inner salt, [R-(R*,S*)] -
• (6R)-5,10-methenyltetrahydrofolic acid
• Folic Acid Impurity 14
• 5,10-Methenyltetrahydrofolic acid
• (6R,S)-5,10-Methenyl-5,6,7,8-tetrahydrofolic Acid