CAS 74469-00-4

Amoxicillin-potassium clavulanate mixt.

Description:

Amoxicillin-potassium clavulanate mixt., commonly known as co-amoxiclav, is a combination antibiotic that includes amoxicillin, a penicillin derivative, and clavulanate potassium, a beta-lactamase inhibitor. This combination enhances the efficacy of amoxicillin against a broader spectrum of bacteria, particularly those that produce beta-lactamase enzymes, which can render penicillins ineffective. The substance appears as a white to off-white powder and is typically administered orally in various formulations, including tablets and suspensions. It is effective against a range of infections, including respiratory tract infections, urinary tract infections, and skin infections. The mechanism of action involves amoxicillin inhibiting bacterial cell wall synthesis, while clavulanate protects amoxicillin from degradation by beta-lactamase enzymes. The pharmacokinetics of this mixture indicate good absorption and distribution in body tissues, with renal excretion being the primary route of elimination. As with any antibiotic, appropriate use is crucial to minimize the development of antibiotic resistance.

Formula: C₁₆H₁₉N₃O₅S·C₈H₉NO₅·K

InChI: InChI=1S/C16H19N3O5S.C8H9NO5.K/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);1,6-7,10H,2-3H2,(H,12,13);/b;4-1-;/t9-,10-,11+,14-;6-,7-;/m11./s1

InChI key: InChIKey=VKJFJOFNYVFTRZ-ZVDZYBSKSA-N

SMILES: C(O)(=O)[C@@H]\1N2[C@](O/C1=C\CO)(CC2=O)[H].[K].C(O)(=O)[C@@H]1N2[C@@]([C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C2=O)(SC1(C)C)[H]

Synonyms:

• (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (1:1)
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-, mixt. with (2S,5R,6R)-6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2α,3Z,5α)]-, mixt. with [2S-[2α,5α,6β(S*)]]-6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-, mixt. with (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-, mixt. contg.
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2α,5α,6β(S*)]]-, mixt. contg.
• Amocla
• Amoclan
• Amoclav
• Amoran
• Amox-clav
• Amoxicillin-clavulanate potassium mixt.
• Amoxicillin-potassium clavulanate mixt.
• Amoxyclav
• Ancla
• Augmentan
• Augmentin
• Augmentin (antibiotic)
• Augmentin ES 600
• Augmentine
• Auspilic
• Brl 25000
• Brl 25000A
• Brl 25000G
• Clamentin
• Clamobit
• Clamonex
• Clamoxyl
• Clavamox
• Clavinex
• Clavoxilin Plus
• Clavulin
• Clavumox
• Eumetinex
• Forcid Solutab
• Kmoxilin
• Proclav S
• Spectramox
• Viaclav
• Xiclav
• co-Amoxyclav

Augmentin

Controlled Product

CAS: 74469-00-4

Formula: (C₁₆H₁₉N₃O₅S)•(C₈H₈KNO₅)

Color and Shape: Beige

Molecular weight: 4365.4023725

Ref: TR-A794740

Augmentin

CAS: 74469-00-4

Formula: (C₁₆H₁₉N₃O₅S)C₈H₈KNO₅

Molecular weight: 4(365.40) : 237.35

Ref: ST-EA-CP-A20071

Amoxicillin-clavulanate potassium

CAS: 74469-00-4

Amoxicillin-clavulanate potassium is an orally administered antibiotic and combination agent indicated for various bacterial infections.

Formula: C₂₄H₂₇KN₄O₁₀S

Purity: 98%

Color and Shape: Solid

Molecular weight: 602.66

Ref: TM-T78628